Sepsis is a significant cause of mortality in critically ill patients. Acute lung injury (ALI) is a
leading cause of death in these patients. Endothelial cells exposed to the bacterial …

Summary Caspase-11, a cytosolic endotoxin (lipopolysaccharide: LPS) receptor, mediates
pyroptosis, a lytic form of cell death. Caspase-11-dependent pyroptosis mediates lethality in …

Hemorrhagic shock (HS) often renders patients more susceptible to lung injury by priming
for an exaggerated response to a second infectious stimulus. Acute lung injury (ALI) is a …

Background Endothelial injury is one of the predominant pathophysiological characteristics
of sepsis and is the major cause of sepsis-induced multiple organ failure. Endothelial …

Sepsis, an inflammatory syndrome secondary to infection, is the leading cause of in-hospital
lethality. It is evidenced that LPS, the major pathological component of the Gram-negative …

Abstract Caspase-11, a cytosolic lipopolysaccharide (LPS) receptor, mediates lethal
immune responses and coagulopathy in sepsis, a leading cause of death worldwide with …

Gram-negative sepsis is a severe clinical syndrome associated with significant morbidity
and mortality. Lipopolysaccharide (LPS), expressed on Gram-negative bacteria, is a potent …

The identification of HMGB1 as a late mediator in sepsis has highlighted HMGB1 as a
promising therapeutic target for sepsis treatment. Recent studies have revealed that annexin …

Heparin, a mammalian polysaccharide, is a widely used anticoagulant medicine to treat
thrombotic disorders. It is also known to improve outcomes in sepsis, a leading cause of …

Endothelial cells injury and pro-inflammation cytokines release are the initial steps of
hyperhomocysteinemia (HHcy)-associated vascular inflammation. Pyroptosis is a newly …