Abnormal placentation has been noticed in a variety of pregnancy complications such as
miscarriage, early-onset preeclampsia, and fetal growth restriction. Defects in the …

Invasive, extravillous trophoblasts (EVT) of the human placenta are critically involved in
successful pregnancy outcome since they remodel the uterine spiral arteries to increase …

The transformation of cytotrophoblast (CTB) to extravillous trophoblast (EVT) is an essential
process for placental implantation. EVT generated at the tips of the anchoring villi migrate …

During placentation invasive extravillous trophoblasts (EVTs) migrate into the maternal
uterus and modify its vessels. In particular, remodeling of the spiral arteries by EVTs is …

A fundamental step in embryonic development is cell differentiation whereby highly
specialised cell types are developed from a single undifferentiated, fertilised egg. One of the …

Defective placentation is the underlying cause of various pregnancy complications, such as
severe intrauterine growth restriction and preeclampsia. However, studies on human …

The establishment of a functional placenta is pivotal for normal fetal development and the
maintenance of pregnancy. In the course of early placentation, trophoblast precursors …

The human placenta contains two specialized regions: the villous chorion where gases and
nutrients are exchanged between maternal and fetal blood, and the smooth chorion (SC) …

Differentiation of first trimester human placental cytotrophoblast (CTB) from an anchorage-
dependent epithelial phenotype into the mesenchymal-like invasive extravillous trophoblast …

During pregnancy, invading HLA-G+ extravillous trophoblasts (EVT) play a key role in
placental development, uterine spiral artery remodeling, and prevention of detrimental …