Neutrophil-platelet interactions as novel treatment targets in cardiovascular disease

R Kaiser, R Escaig, J Erber, L Nicolai - Frontiers in cardiovascular …, 2022 - frontiersin.org
Neutrophils and platelets are among the most abundant cell types in peripheral blood and
characterized by high plasticity and a readily available reservoir of surface proteins and …

Platelet–Neutrophil Crosstalk in Thrombosis

LJ Mereweather, A Constantinescu-Bercu… - International journal of …, 2023 - mdpi.com
Platelets are essential for the formation of a haemostatic plug to prevent bleeding, while
neutrophils are the guardians of our immune defences against invading pathogens. The …

Neutrophils in cardiovascular disease: warmongers, peacemakers, or both?

G Sreejit, J Johnson, RM Jaggers… - Cardiovascular …, 2022 - academic.oup.com
Neutrophils, the most abundant of all leucocytes and the first cells to arrive at the sites of
sterile inflammation/injury act as a double-edged sword. On one hand, they inflict a …

Platelet–neutrophil interactions as drivers of inflammatory and thrombotic disease

T Lisman - Cell and tissue research, 2018 - Springer
Neutrophils are well known for their role in infection and inflammatory disease and are first
responders at sites of infection or injury. Platelets have an established role in hemostasis …

[HTML][HTML] Role of neutrophils, platelets, and extracellular vesicles and their interactions in COVID‐19‐associated thrombopathy

A Caillon, A Trimaille, J Favre, L Jesel, O Morel… - Journal of Thrombosis …, 2022 - Elsevier
The COVID‐19 pandemic extended all around the world causing millions of deaths. In
addition to acute respiratory distress syndrome, many patients with severe COVID‐19 …

Misunderstandings between platelets and neutrophils build in chronic inflammation

GA Ramirez, AA Manfredi, N Maugeri - Frontiers in immunology, 2019 - frontiersin.org
Regulated hemostasis, inflammation and innate immunity entail extensive interactions
between platelets and neutrophils. Under physiological conditions, vascular inflammation …

Platelets in atherothrombosis: new and evolving roles

A Weyrich, F Cipollone, A Mezzetti… - Current …, 2007 - ingentaconnect.com
The functional interplay of platelets with leukocytes and endothelial cells is critical both in
physiological conditions, such as host defense, wound repair and tissue healing, and in …

Platelet-neutrophil interplay: insights into neutrophil extracellular trap (NET)-driven coagulation in infection

AZ Zucoloto, CN Jenne - Frontiers in cardiovascular medicine, 2019 - frontiersin.org
Well established for their central role in hemostasis, platelets have increasingly been
appreciated as immune cells in recent years. This emerging role should not come as a …

Immunothrombosis and thromboinflammation in host defense and disease

K Martinod, C Deppermann - Platelets, 2021 - Taylor & Francis
Platelets are increasingly being recognized for playing roles beyond thrombosis and
hemostasis. Today we know that they mediate inflammation by direct interactions with innate …

Platelets in neutrophil recruitment to sites of inflammation

S Pitchford, D Pan, HCE Welch - Current opinion in hematology, 2017 - journals.lww.com
Recent findings have contributed to our burgeoning understanding of the platelet-dependent
mechanisms that control neutrophil recruitment to sites of inflammation and have opened up …