Predator stress-induced CRF release causes enduring sensitization of basolateral amygdala norepinephrine systems that promote PTSD-like startle abnormalities
AK Rajbhandari, BA Baldo, VP Bakshi - Journal of Neuroscience, 2015 - Soc Neuroscience
The neurobiology of post-traumatic stress disorder (PTSD) remains unclear. Intense stress
promotes PTSD, which has been associated with exaggerated startle and deficient …
promotes PTSD, which has been associated with exaggerated startle and deficient …
Locus coeruleus norepinephrine drives stress-induced increases in basolateral amygdala firing and impairs extinction learning
Stress impairs extinction learning, and these deficits depend, in part, on stress-induced
norepinephrine (NE) release in the basolateral amygdala (BLA). For example, systemic or …
norepinephrine (NE) release in the basolateral amygdala (BLA). For example, systemic or …
Investigation of a central nucleus of the amygdala/dorsal raphe nucleus serotonergic circuit implicated in fear-potentiated startle
BM Spannuth, MW Hale, AK Evans, JL Lukkes… - Neuroscience, 2011 - Elsevier
Serotonergic systems are thought to play an important role in control of motor activity and
emotional states. We used a fear-potentiated startle paradigm to investigate the effects of a …
emotional states. We used a fear-potentiated startle paradigm to investigate the effects of a …
Corticotropin-releasing factor receptors CRF1 and CRF2 exert both additive and opposing influences on defensive startle behavior
VB Risbrough, RL Hauger, AL Roberts… - Journal of …, 2004 - Soc Neuroscience
The corticotropin-releasing factor (CRF) receptors (CRF1 and CRF2) are crucial mediators
of physiological and behavioral responses to stress. In animals, CRF1 appears to primarily …
of physiological and behavioral responses to stress. In animals, CRF1 appears to primarily …
[HTML][HTML] Single-prolonged stress impairs prefrontal cortex control of amygdala and striatum in rats
VM Piggott, KE Bosse, MJ Lisieski… - Frontiers in Behavioral …, 2019 - frontiersin.org
Medial prefrontal cortex (mPFC), amygdala, and striatum neurocircuitry has been shown to
play an important role in post-traumatic stress disorder (PTSD) pathology in humans …
play an important role in post-traumatic stress disorder (PTSD) pathology in humans …
CRF receptor blockade prevents initiation and consolidation of stress effects on affect in the predator stress model of PTSD
R Adamec, D Fougere… - International Journal of …, 2010 - academic.oup.com
Post traumatic stress disorder (PTSD) is a chronic anxiety disorder initiated by an intensely
threatening, traumatic event. There is a great need for more efficacious pharmacotherapy …
threatening, traumatic event. There is a great need for more efficacious pharmacotherapy …
The role of norepinephrine in differential response to stress in an animal model of posttraumatic stress disorder
VG Olson, HR Rockett, RK Reh, VA Redila, PM Tran… - Biological …, 2011 - Elsevier
BACKGROUND: Posttraumatic stress disorder (PTSD) is a prevalent psychiatric disorder
precipitated by exposure to extreme traumatic stress. Yet, most individuals exposed to …
precipitated by exposure to extreme traumatic stress. Yet, most individuals exposed to …
Oxytocin receptors in the dorsolateral bed nucleus of the stria terminalis (BNST) bias fear learning toward temporally predictable cued fear
D Martinon, P Lis, AN Roman, P Tornesi… - Translational …, 2019 - nature.com
The inability to discriminate between threat and safety is a hallmark of stress-induced
psychiatric disorders, including post-traumatic stress disorder. Dorsolateral bed nucleus of …
psychiatric disorders, including post-traumatic stress disorder. Dorsolateral bed nucleus of …
CRF1 and CRF2 receptors are required for potentiated startle to contextual but not discrete cues
VB Risbrough, MA Geyer, RL Hauger, S Coste… - …, 2009 - nature.com
Corticotropin-releasing factor (CRF) peptides and their receptors have crucial roles in
behavioral and endocrine responses to stress. Dysregulation of CRF signaling has been …
behavioral and endocrine responses to stress. Dysregulation of CRF signaling has been …
Unilateral block of NMDA receptors in the amygdala prevents predator stress-induced lasting increases in anxiety-like behavior and unconditioned startle—effective …
RE Adamec, P Burton, T Shallow, J Budgell - Physiology & Behavior, 1998 - Elsevier
Effective hemisphere depends on the behavior. PHYSIOL BEHAV 65 (4/5) 739–751, 1999.—
Lasting increases in anxiety-like behavior (ALB) in the elevated plus-maze are produced by …
Lasting increases in anxiety-like behavior (ALB) in the elevated plus-maze are produced by …