Effects of mesenchymal stromal cell-derived extracellular vesicles in lung diseases: current status and future perspectives

H Guo, Y Su, F Deng - Stem cell reviews and reports, 2021 - Springer
Mesenchymal stromal cells (MSCs) as a kind of pluripotent adult stem cell have shown great
therapeutic potential in relation to many diseases in anti-inflammation and regeneration. The …

[HTML][HTML] Mesenchymal stromal cell-derived extracellular vesicles in lung diseases: current status and perspectives

SC Abreu, M Lopes-Pacheco, DJ Weiss… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) have emerged as a potential therapy for several diseases.
These plasma membrane-derived fragments are released constitutively by virtually all cell …

Clinical application of mesenchymal stem cell-derived extracellular vesicle-based therapeutics for inflammatory lung diseases

Y Fujita, T Kadota, J Araya, T Ochiya… - Journal of Clinical …, 2018 - mdpi.com
It is currently thought that extracellular vesicles (EVs), such as exosomes and microvesicles,
play an important autocrine/paracrine role in intercellular communication. EVs package …

Mesenchymal stem/stromal cell secretome for lung regeneration: The long way through “pharmaceuticalization” for the best formulation

E Bari, I Ferrarotti, ML Torre, AG Corsico… - Journal of Controlled …, 2019 - Elsevier
Pulmonary acute and chronic diseases, such as chronic obstructive pulmonary disease,
pulmonary fibrosis and pulmonary hypertension, are considered to be major health issues …

[HTML][HTML] Emerging therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in chronic respiratory diseases: an overview of recent progress

Y Ma, X Liu, Y Long, Y Chen - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are able to carry genetic
and protein goods to mediate the interaction between MSCs and target cells. Recently, more …

Mesenchymal stromal cell extracellular vesicles as therapy for acute and chronic respiratory diseases: A meta‐analysis

A Tieu, K Hu, C Gnyra, J Montroy… - Journal of …, 2021 - Wiley Online Library
Preclinical studies suggest mesenchymal stromal cell extracellular vesicles (MSC‐EVs)
reduce inflammation and improve organ function in lung diseases; however, an objective …

Extracellular vesicles derived from mesenchymal stromal cells: a therapeutic option in respiratory diseases?

SC Abreu, DJ Weiss, PRM Rocco - Stem cell research & therapy, 2016 - Springer
Extracellular vesicles (EVs) are plasma membrane-bound fragments released from several
cell types, including mesenchymal stromal cells (MSCs), constitutively or under stimulation …

Therapeutic use of extracellular vesicles for acute and chronic lung disease

EN Worthington, JS Hagood - International journal of molecular sciences, 2020 - mdpi.com
Multipotent mesenchymal stem cells (MSCs) possess regenerative properties and have
been shown to improve outcomes and survival in acute and chronic lung diseases, but there …

Mesenchymal stem cell derived secretome and extracellular vesicles for acute lung injury and other inflammatory lung diseases

A Monsel, Y Zhu, V Gudapati, H Lim… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Acute respiratory distress syndrome is a major cause of respiratory failure in
critically ill patients. Despite extensive research into its pathophysiology, mortality remains …

Therapeutic potential of mesenchymal stem/stromal cell-derived secretome and vesicles for lung injury and disease

A Liu, X Zhang, H He, L Zhou, Y Naito… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: The acute respiratory distress syndrome (ARDS) is a devastating clinical
condition common in patients with respiratory failure. Based largely on numerous preclinical …