Induction of Adhesion-Inhibitory Antibodies against Placental Plasmodium falciparum Parasites by Using Single Domains of VAR2CSA
MA Nielsen, VV Pinto, M Resende… - Infection and …, 2009 - Am Soc Microbiol
In areas of endemicity pregnancy-associated malaria is an important cause of maternal
anemia, stillbirth, and delivery of low-birth-weight children. The syndrome is precipitated by …
anemia, stillbirth, and delivery of low-birth-weight children. The syndrome is precipitated by …
Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates
M Avril, MJ Hathaway, A Srivastava, S Dechavanne… - PloS one, 2011 - journals.plos.org
The high molecular weight, multidomain VAR2CSA protein mediating adhesion of
Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a …
Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a …
Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins
Background Pregnancy associated malaria is a severe clinical syndrome associated with
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …
Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies
Abstract Background Malaria caused by Plasmodium falciparum can result in several
different syndromes with severe clinical consequences for the about 200 million individuals …
different syndromes with severe clinical consequences for the about 200 million individuals …
Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria
M Fried, M Avril, R Chaturvedi, P Fernandez… - Infection and …, 2013 - Am Soc Microbiol
Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes that adhere to
the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women …
the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women …
High levels of antibodies to multiple domains and strains of VAR2CSA correlate with the absence of placental malaria in Cameroonian women living in an area of high …
YL Tutterrow, M Avril, K Singh, CA Long… - Infection and …, 2012 - Am Soc Microbiol
Placental malaria, caused by sequestration of Plasmodium falciparum-infected erythrocytes
in the placenta, is associated with increased risk of maternal morbidity and poor birth …
in the placenta, is associated with increased risk of maternal morbidity and poor birth …
Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites
P Fernandez, NK Viebig, S Dechavanne, C Lépolard… - Malaria Journal, 2008 - Springer
Background Pregnancy-associated malaria (PAM) is a serious consequence of Plasmodium
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …
Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA
M Avril, BR Kulasekara, SO Gose, C Rowe… - Infection and …, 2008 - Am Soc Microbiol
Pregnancy-associated malaria (PAM) is characterized by the placental sequestration of
Plasmodium falciparum-infected erythrocytes (IEs) with the ability to bind to chondroitin …
Plasmodium falciparum-infected erythrocytes (IEs) with the ability to bind to chondroitin …
Identification of VAR2CSA domain-specific inhibitory antibodies of the Plasmodium falciparum erythrocyte membrane protein 1 using a novel flow cytometry assay
H Obiakor, M Avril, NJ MacDonald… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
ABSTRACT VAR2CSA, a member of the Plasmodium falciparum erythrocyte membrane
protein 1 (PfEMP1) family, is a leading candidate for use in vaccines to protect first-time …
protein 1 (PfEMP1) family, is a leading candidate for use in vaccines to protect first-time …
[HTML][HTML] Differential adhesion-inhibitory patterns of antibodies raised against two major variants of the NTS-DBL2X region of VAR2CSA
J Doritchamou, P Bigey, MA Nielsen, S Gnidehou… - Vaccine, 2013 - Elsevier
Background VAR2CSA is a large polymorphic Plasmodium falciparum protein expressed on
infected erythrocytes (IE) that allows their binding in the placenta, thus precipitating …
infected erythrocytes (IE) that allows their binding in the placenta, thus precipitating …