Macrophage has been gradually recognized as a central regulator in tissue regeneration,
and the study of how macrophage mediates biomaterials-induced bone regeneration …

Biomaterials as bone substitutes are always considered as foreign bodies that can trigger
host immune responses. Traditional designing principles have been always aimed at …

A coordinated interaction between osteogenesis and osteoimmune microenvironment is
essential for successful bone healing. In particular, macrophages play a central regulatory …

Bone is a self-regenerative tissue that can repair small defects and fractures. In large
defects, bone tissue is unable to provide nutrients and oxygen for repair, and autologous …

Bone healing is associated with many orthopedic conditions, including fractures and
osteonecrosis, arthritis, metabolic bone disease, tumors and periprosthetic particle …

Background Bone formation and remodeling are influenced by the inflammatory state of the
local microenvironment. In this regard, macrophages are postulated to play a crucial role in …

Recent research has brought about a clear understanding that successful fracture healing is
based on carefully coordinated cross-talk between inflammatory and bone forming cells. In …

With an increasingly aging society, bone defects and fractures have become significant
threats to human health and quality of life. Currently, autologous and allogeneic bone grafts …

The past decade has seen a growing appreciation for the role of the innate immune
response in mediating repair and biomaterial directed tissue regeneration. The long-held …

Osseointegration seems to be a foreign body reaction equilibrium due to the complicated
interactions between the immune and skeletal systems. The heterogeneity of the …