Chronic melatonin consumption prevents obesity‐related metabolic abnormalities and protects the heart against myocardial ischemia and reperfusion injury in a …

F Nduhirabandi, EF Du Toit, D Blackhurst… - Journal of pineal …, 2011 - Wiley Online Library
Obesity, a major risk factor for ischemic heart disease, is associated with increased oxidative
stress and reduced antioxidant status. Melatonin, a potent free radical scavenger and …

Short‐term melatonin consumption protects the heart of obese rats independent of body weight change and visceral adiposity

F Nduhirabandi, B Huisamen, H Strijdom… - Journal of pineal …, 2014 - Wiley Online Library
Chronic melatonin treatment has been shown to prevent the harmful effects of diet‐induced
obesity and reduce myocardial susceptibility to ischaemia‐reperfusion injury (IRI). However …

Melatonin ameliorates myocardial infarction in obese diabetic individuals: The possible involvement of macrophage apoptotic factors

J Maity, T Dey, A Banerjee… - Journal of Pineal …, 2023 - Wiley Online Library
In recent days, the hike in obesity‐mediated epidemics across the globe and the prevalence
of obesity‐induced cardiovascular disease has become one of the chief grounds for …

Melatonin protects against isoproterenol‐induced alterations in cardiac mitochondrial energy‐metabolizing enzymes, apoptotic proteins, and assists in complete …

D Mukherjee, AK Ghosh… - Journal of pineal …, 2012 - Wiley Online Library
The present study was undertaken to explore the protective effect of melatonin against
isoproterenol bitartrate (ISO)‐induced rat myocardial injury and to test whether melatonin …

Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet‐induced metabolic syndrome in rats

P Cano Barquilla, ES Pagano… - Journal of pineal …, 2014 - Wiley Online Library
The objective of this study was to evaluate the efficacy of melatonin to affect mild
inflammation in the metabolic syndrome (MS) induced by a high‐fat diet in rats. Adult Wistar …

Melatonin protects against ischemic heart failure in rats

AÖ Şehirli, D Koyun, Ş Tetik, D Özsavcı… - Journal of pineal …, 2013 - Wiley Online Library
Ischemic injury, which occurs as a result of sympathetic hyperactivity, plays an important role
in heart failure. Melatonin is thought to have antiatherogenic, antioxidant, and vasodilatory …

Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic fatty rats

A Agil, M Navarro‐Alarcón, R Ruiz… - Journal of pineal …, 2011 - Wiley Online Library
The study objective was to investigate the effects of melatonin on obesity and obesity‐
associated systolic hypertension and dyslipidemia in young male Zucker diabetic fatty (ZDF) …

Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: a randomized, double …

F Raygan, V Ostadmohammadi, F Bahmani, RJ Reiter… - Clinical Nutrition, 2019 - Elsevier
Background & aims Melatonin may benefit diabetic people with coronary heart disease
(CHD) through its beneficial effects on biomarkers of oxidative stress and cardio-metabolic …

Melatonin supplementation lowers oxidative stress and regulates adipokines in obese patients on a calorie‐restricted diet

K Szewczyk-Golec, P Rajewski… - Oxidative medicine …, 2017 - Wiley Online Library
Obesity is one of the major global health problems. Melatonin deficiency has been
demonstrated to correlate with obesity. The aim of the study was to estimate the effect of …

Intake of melatonin is associated with amelioration of physiological changes, both metabolic and morphological pathologies associated with obesity: an animal model

MR Hussein, OG Ahmed, AF Hassan… - International journal …, 2007 - Wiley Online Library
Obesity and its associated metabolic pathologies are the most common and detrimental
diseases, affecting over 50% of the adult population. Our knowledge about the protective …