Introduction: The rising prevalence of obesity confronts clinicians with dosing problems in
the (extreme) overweight population. Obesity has a great impact on key organs that play a …

Introduction: The prevalence of obesity and associated co-morbid conditions is increasing
globally. Physiological changes accompanying obesity are likely to result in altered drug …

Obesity is a pathophysiological state defined by a body mass index> 30 kg/m 2 and
characterized by an adipose tissue accumulation leading to an important weight increased …

Obesity has become a worldwide challenge with significant health and socioeconomic
implications. One of the major implications is its impact on drug therapy. In order to gain a …

Drug disposition for many drugs has now been studied in obese individuals and some
general conclusions can be drawn. Absorption of drugs evaluated to date is unchanged due …

Obesity is a disease characterized as a condition resulting from the excess accumulation of
body fat. In conjunction with increased stores of body fat, obesity has also been associated …

Introduction Obesity is associated with many physiological changes. We review available
evidence regarding five commonly accepted assumptions to a priori predict the impact of …

The prevalence of obesity in adults and children is rapidly increasing across the world.
Several general (patho) physiological alterations associated with obesity have been …

The global epidemic of obesity has led to an increased prevalence of chronic diseases and
need for pharmacological intervention. However, little is known about the influence of …

Obesity is a worldwide problem, with major health, social and economic implications. The
adaptation of drug dosages to obese patients is a subject of concern, particularly for drugs …