Simple Summary B7-H3 costimulatory ligand has sparked tremendous interest as a target
for antibody-directed therapy of solid tumors. This is attributed to high expression of B7-H3 …

Abstract Background B7-H3, an immune-checkpoint molecule and a transmembrane
protein, is overexpressed in non-small cell lung cancer (NSCLC), making it an attractive …

Activating NK cell receptors represent promising target structures to elicit potent antitumor
immune responses. In this study, novel immunoligands were generated that bridge the …

Natural Killer (NK) cells are innate effector cells that are able to recognize and eliminate
tumor cells through engagement of their surface receptors. NKp30 is a potent activating NK …

Natural killer (NK) cells are central effector cells during innate immune responses against
cancer. Natural cytotoxicity receptors expressed by NK cells such as NKp30 are involved in …

Cancer development is often associated with the lack of specific and efficient recognition of
tumor cells by the immune system. Natural killer (NK) cells are lymphocytes of the innate …

Introduction The Fc region of monoclonal antibodies (mAbs) interacts with the CD16a
receptor on natural killer (NK) cells with “low affinity” and “low selectivity”. This low …

Immune cells are believed to participate in initiating anti-tumor effects during regular tumor
therapy such as chemotherapy, radiation, hyperthermia, and cytokine injection. One of the …

Induced self expression of the NKp30 ligand B7-H6 facilitates NK cell-mediated elimination
of stressed cells. A fusion protein consisting of the ectodomain of B7-H6 and the CD20 …

Abstract B7-H4 (VTCN1, B7x, B7s) is a ligand for inhibitory coreceptors on T cells implicated
in antigenic tolerization. B7-H4 is expressed by tumor cells and tumor-associated …