From this discussion, several conclusions can be drawn. First, with advancing age there is a
decrease in cardiovascular responsiveness and, more specifically, there is a decrease in …

Catecholamines have an important endocrine and neuroendocrine role in mediating a
variety of autonomic functions. One consequence of normal aging, in particular in the …

To elucidate the association of β-adrenergic receptors with decreased myocardial
catecholamine responsiveness in aging, we investigated the chronotropic response to …

Introduction: The possible effect of ageing on adrenergic mechanisms has been one of the
most studied of the pharmacodynamic processes affecting responsiveness to drugs in old …

When perspectives from studies that range from measurements of the stress response in
intact humans to measurements of subcellular biochemistry in animal models are integrated …

To investigate the mechanism of receptor changes associated with aging, we developed a
beta-adrenergic receptor assay in whole human lymphocytes which fulfills strict affinity …

Studies evaluating plasma norepinephrine in the normal elderly have found significant
increases as compared to the young and middle-aged individuals. The increased plasma …

Recent studies in our laboratory suggest that the synthesis of alpha-and beta-adrenergic
receptors in certain tissues from brain and pineal gland may be impaired with age. This …

Cardiovascular adaptation to stress is highly dependent on adrenergic stimulation. It may be
hypothesized that the diminished cardiovascular response to acute stress that occurs in …

The effect of age on presynaptic alpha2 adrenoceptor-mediated regulation of
norepinephrine (NE) release was studied in hearts isolated from male fischer 344 rats 6-, 12 …