Intracellular peptides (InPeps) generated by proteasomes were previously suggested as
putative natural regulators of protein–protein interactions (PPI). Here, the main aim was to …

Cancer therapy is limited, in part, by lack of specificity. Thus, identifying molecules that are
selectively expressed by, and relevant for, cancer cells is of paramount medical importance …

ATG4B facilitates autophagy by promoting autophagosome maturation through the
reversible lipidation and delipidation of LC3. Recent reports have shown that …

Mammalian target of rapamycin (mTOR) signaling is a core pathway in cellular metabolism,
and control of the mTOR pathway by rapamycin shows potential for the treatment of …

Abstract FK506 binding protein 5 (FKBP5) belongs to a family of immunophilins named for
their ability to bind immunosuppressive drugs, also known as peptidyl-prolyl cis-trans …

Background FK506 binding protein 51 (FKBP51) is an Hsp90 co-chaperone and regulator of
the glucocorticoid receptor, and consequently of stress physiology. Clinical studies suggest …

Background Rapamycin-induced translocation systems can be used to manipulate
biological processes with precise temporal control. These systems are based on rapamycin …

We have recently shown that the immunophilin FKBP5 (also known as FKBP51) is a
scaffolding protein that can enhance PHLPP-AKT interaction and facilitate PHLPP-mediated …

Abstract The FK506-binding protein 51 (FKBP51, encoded by FKBP5 gene) has emerged as
a critical regulator of mammalian endocrine stress responses and as a potential …

Autophagy is a homeostatic process by which misfolded proteins, organelles and
cytoplasmic material are engulfed in autophagosomal vesicles and degraded through a …