[HTML][HTML] Curcumin combined with FOLFOX chemotherapy is safe and tolerable in patients with metastatic colorectal cancer in a randomized phase IIa trial

LM Howells, COO Iwuji, GRB Irving, S Barber… - The Journal of …, 2019 - Elsevier
Background Curcumin is the main active ingredient of the spice turmeric, investigated
extensively for putative anticancer properties. Objectives This phase IIa open-labelled …

Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a …

GRB Irving, COO Iwuji, B Morgan, DP Berry… - Trials, 2015 - Springer
Background The need for low toxicity adjuncts to standard care chemotherapy in inoperable
colorectal cancer, with potential to improve outcomes and decrease the side-effect burden …

Synergistic role of curcumin with current therapeutics in colorectal cancer: minireview

BB Patel, APN Majumdar - Nutrition and cancer, 2009 - Taylor & Francis
Despite the use of surgical resection and aggressive chemotherapy, nearly 50% of patients
with colorectal carcinoma develop recurrent disease, highlighting the need for improved …

Curcumin: A therapeutic strategy for colorectal cancer?

VR de Porras, L Layos, E Martínez-Balibrea - Seminars in cancer biology, 2021 - Elsevier
Colorectal cancer (CRC) is the second cause of cancer death worldwide. The metastatic
disease is mainly treated with aggressive therapies consisting on combinations of cytotoxic …

Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration—a clinical pilot study including assessment of patient acceptability

GRB Irving, LM Howells, S Sale, I Kralj-Hans… - Cancer prevention …, 2013 - AACR
Curcumin, the main constituent of turmeric, is suspected to possess cancer chemopreventive
properties. Pharmacokinetic and pharmacodynamic parameters have been reported, but few …

Dose escalation of a curcuminoid formulation

CD Lao, MT Ruffin, D Normolle, DD Heath… - … and alternative medicine, 2006 - Springer
Background Curcumin is the major yellow pigment extracted from turmeric, a commonly-
used spice in India and Southeast Asia that has broad anticarcinogenic and cancer …

Curcumin targets FOLFOX-surviving colon cancer cells via inhibition of EGFRs and IGF-1R

BB Patel, D Gupta, AA Elliott, V Sengupta… - Anticancer …, 2010 - ar.iiarjournals.org
Curcumin (diferuloylmethane), which has no discernible toxicity, inhibits initiation, promotion
and progression of carcinogenesis. 5-Fluorouracil (5-FU) or 5-FU plus oxaliplatin (FOLFOX) …

[HTML][HTML] Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with …

MI James, C Iwuji, G Irving, A Karmokar, JA Higgins… - Cancer letters, 2015 - Elsevier
In vitro and pre-clinical studies have suggested that addition of the diet-derived agent
curcumin may provide a suitable adjunct to enhance efficacy of chemotherapy in models of …

New mechanisms and therapeutic potential of curcumin for colorectal cancer

I Villegas, S Sánchez‐Fidalgo… - Molecular nutrition & …, 2008 - Wiley Online Library
Curcumin is a polyphenol derived from Curcuma longa. Over the last few years, a number of
studies have provided evidence of its main pharmacological properties including …

Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions

J Adiwidjaja, AJ McLachlan… - Expert opinion on drug …, 2017 - Taylor & Francis
Introduction: Curcumin has been extensively studied for its anti-cancer properties. While a
diverse array of in vitro and preclinical research support the prospect of curcumin use as an …