As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction
via protein phosphorylation cascades. Insulin action on signal transduction is impaired in …

Type 2 (non-insulin-dependent) diabetes mellitus afflicts millions of people worldwide and is
one of the main causes of morbidity and mortality. Current therapeutic agents to treat Type 2 …

Introduction 3. Glucose transport regulation: Insulin signal transduction and GLUT4 vesicle
traffic 4. Defects in insulin signal transduction and GLUT4 translocation 5. Altered metabolic …

The skeletal muscle is the largest organ in the body, by mass. It is also the regulator of
glucose homeostasis, responsible for 80% of postprandial glucose uptake from the …

Skeletal muscle is the largest tissues in the human body and is considered the primary
target for insulin-stimulated glucose disposal. In skeletal muscle, binding of the insulin to …

Type II diabetes is characterized by defects in insulin action on peripheral tissues, such as
skeletal muscle, adipose tissue and liver and pancreatic β-cell defects. Since the skeletal …

Among all the varied actions of insulin, regulation of glucose homeostasis is the most critical
and intensively studied. With the availability of glucose from nutrient metabolism, insulin …

Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …

Skeletal muscle has a fundamentally important role in the maintenance of normal glucose
homeostasis and in regulating whole-body carbohydrate metabolism. In this review, we …