Microglia are the immune effector cells of the brain playing critical roles in immune
surveillance and neuroprotection in healthy conditions, while they can sustain …

Parkinson's disease is a progressive, age-related, neurodegenerative disorder, and
oxidative stress is an important mediator in its pathogenesis. DJ-1 has been identified as a …

Abstract Parkinson's disease (PD), one of the most common neurodegenerative disorders, is
characterized by progressive neurodegeneration of dopaminergic (DA) neurons in the …

Mutations in the PARK7/DJ-1 gene are rare causes of autosomal-recessive hereditary
Parkinson's disease. Loss-of-function mutations lead to the characteristic selective …

Several mutations in the gene coding for DJ-1 have been associated with early onset forms
of parkinsonism. In spite of the massive effort spent by the scientific community in …

DJ‐1 is an oxidative stress sensor that localizes to the mitochondria when the cell is
exposed to oxidative stress. DJ‐1 mutations that result in gene deficiency are linked to …

Efforts have been made to understand the physiological and pathological role of DJ-1, a
Parkinson's disease (PD)-associated protein, to provide new insights into PD …

Astrocytes are the most abundant glial cell type in the brain. Impairment in astrocyte
functions can critically influence neuronal survival and leads to neurodegeneration …

Mutation of DJ-1 (PARK7) has been linked to the development of early-onset Parkinson's
disease (PD). However, the underlying molecular mechanism is still unclear. This study is …

Mutations in DJ-1, reactive gliosis and concomitant inflammatory processes are implicated in
the pathogenesis and progression of Parkinson's disease (PD). To study the physiological …