Transglutaminase 2 (TG2) is a multifunctional enzyme and two isoforms, TG2-L and TG2-S,
exerting opposite effects in the regulation of cell death and survival, have been revealed in …

The expression of hypoxia-inducible factor-1 (HIF-1) correlates with poor clinical outcomes
and confers resistance to the apoptosis of the tumor cells that are exposed to hypoxia …

Osteosarcoma is the most common type of solid bone cancer, which is the second leading
cause of cancer-related death. Hypoxia is an ordinary phenomenon in solid tumor tissues …

Purpose Tissue transglutaminase 2 (TG2) is a stress-regulated protein and associated with
cancer cell survival. However, the effects of TG2 expression in human non-small-cell lung …

Transglutaminase type 2 (TG2) is the most ubiquitously expressed and well characterized
member of the transglutaminase family. It is a ubiquitous multifunctional enzyme implicated …

Transglutaminase 2 (TG2) is a widely expressed and multifunctional protein that modulates
cell death/survival processes. We have previously shown that TG2 binds to hypoxia …

Abstract Tissue transglutaminase 2 (TG2) is involved in many biological processes, from
wound healing to neurodegeneration. Recently, there has been an increasing interest in this …

Abstract Transglutaminase 2 (TG2) is a multifunctional enzyme that has been implicated in
the pathogenesis of neurodegenerative diseases, ischemia, and stroke. The mechanism by …

Tissue transglutaminase (TG2) is a multifunctional member of the transglutaminase (TGase)
family (EC 2.3. 2.13), which catalyzes in a calcium-dependent reaction the formation of …

The significant influence of tumor microenvironment on malignant cells has been
investigated with enthusiasm in this era of targeted therapy. Transglutaminase 2 (TG2, EC …