Recent evidence has implicated interleukin-7 (IL-7) as a master regulator of T-cell
homeostasis, based upon its essential role in the homeostatic expansion of naive T-cell …

Abstract Interleukin (IL)-7 is known to up-regulate thymopoietic pathways of T-cell
regeneration. Recent work also has shown it to potently enhance thymic-independent …

The capacity of the immune system to respond efficiently to new antigens depends upon a
continuous source of naive CD4+ T cells. Such cells exit from the thymus and join the …

IL-7 is well known as a lymphopoietic cytokine, but recent studies have also identified a
critical role for IL-7 in peripheral T cell homeostasis. IL-7 is well poised to serve as a …

During an immune response, peripheral T-cell populations expand and then contract as the
response subsides, thus maintaining a fairly constant number of CD4 and CD8 T cells …

Interleukin-7 (IL-7) is a homeostatic cytokine for resting T cells with increasing serum and
tissue levels during T cell depletion. In preclinical studies, IL-7 therapy exerts marked …

Thymic-deficient hosts rely primarily on antigen-driven expansion to restore the peripheral T-
cell compartment following T-cell depletion (TCD). The degree to which this thymic …

Interleukin-7 (IL-7) is a cytokine produced predominantly by stromal cells of the thymus and
bone marrow and is essential for lymphopoiesis. This paper reviews the importance of IL-7 …

Summary Interleukin-7 (IL-7) availability determines the size and proliferative state of the
resting T cell pool. However, the mechanisms that regulate steady-state IL-7 amounts are …

T cells require continual presence of extrinsic signals from their in vivo microenvironment to
maintain viability. T cells removed from these signals and placed in tissue culture atrophied …