[HTML][HTML] Redox homeostasis and nrf2-regulated mechanisms are relevant to male infertility

C Signorini, L Saso, S Ghareghomi… - Antioxidants, 2024 - mdpi.com
Infertility represents a significant global health challenge, affecting more than 12% of
couples worldwide, and most cases of infertility are caused by male factors. Several …

Knockout of the transcription factor NRF2 disrupts spermatogenesis in an age-dependent manner

BN Nakamura, G Lawson, JY Chan, J Banuelos… - Free Radical Biology …, 2010 - Elsevier
Oxidative stress occurs when generation of reactive oxygen species (ROS) overwhelms
antioxidant defenses. Oxidative stress has been associated with male infertility. The …

[HTML][HTML] Bioactive Compounds Protect Mammalian Reproductive Cells from Xenobiotics and Heat Stress-Induced Oxidative Distress via Nrf2 Signaling Activation: A …

MZ Khan, A Khan, B Huang, R Wei, X Kou, X Wang… - Antioxidants, 2024 - mdpi.com
Oxidative stress occurs when there is an imbalance between the production of reactive
oxygen species (ROS) and the body's antioxidant defenses. It poses a significant threat to …

Exploring Nrf2 as a therapeutic target in testicular dysfunction

DE Rotimi, OA Ojo, TD Olaolu, OS Adeyemi - Cell and Tissue Research, 2022 - Springer
Testicular dysfunction, a major contributory factor to infertility, has received a lot of attention
over the recent years. Several studies have linked abnormal sperm function and morphology …

[HTML][HTML] Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight

T Hussain, M Kandeel, E Metwally, G Murtaza… - Frontiers in …, 2023 - frontiersin.org
Male infertility is a widely debated issue that affects males globally. There are several
mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with …

Endogenous and exogenous antioxidants as a tool to ameliorate male infertility induced by reactive oxygen species

T R. Dias, D Martin-Hidalgo, B M. Silva… - Antioxidants & redox …, 2020 - liebertpub.com
Significance: Antioxidants are essential for the maintenance of cellular redox
homeodynamics in the male reproductive tract, playing a key role in fertilizing potential …

Reactive oxygen, nitrogen, and sulfur species in human male fertility. A crossroad of cellular signaling and pathology

V Otasevic, A Stancic, A Korac, A Jankovic, B Korac - Biofactors, 2020 - Wiley Online Library
Infertility is a significant global health problem that currently affects one of six couples in
reproductive age. The quality of male reproductive cells dramatically decreased over the last …

Mechanisms of male infertility: role of antioxidants

SA Sheweita, AM Tilmisany… - Current drug …, 2005 - ingentaconnect.com
Defective sperm function is the most common cause of infertility, and until recently, was
difficult to evaluate and treat. Mammalian spermatozoa membranes are rich in poly …

Effects of Reactive Oxygen and Nitrogen Species on Male Fertility

E Muñoz, F Fuentes, R Felmer, ME Arias… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: In recent decades, male fertility has been severely reduced worldwide. The
causes underlying this decline are multifactorial, and include, among others, genetic …

[HTML][HTML] Sperm redox biology challenges the role of antioxidants as a treatment for male factor infertility

E Caroppo, M Dattilo - F&S Reviews, 2022 - Elsevier
In spite of inconclusive or negative outcomes from clinical studies, oral antioxidants are still
largely prescribed to infertile men to improve sperm motility and/or reduce sperm DNA …