[HTML][HTML] Redox homeostasis and nrf2-regulated mechanisms are relevant to male infertility
C Signorini, L Saso, S Ghareghomi… - Antioxidants, 2024 - mdpi.com
Infertility represents a significant global health challenge, affecting more than 12% of
couples worldwide, and most cases of infertility are caused by male factors. Several …
couples worldwide, and most cases of infertility are caused by male factors. Several …
Knockout of the transcription factor NRF2 disrupts spermatogenesis in an age-dependent manner
BN Nakamura, G Lawson, JY Chan, J Banuelos… - Free Radical Biology …, 2010 - Elsevier
Oxidative stress occurs when generation of reactive oxygen species (ROS) overwhelms
antioxidant defenses. Oxidative stress has been associated with male infertility. The …
antioxidant defenses. Oxidative stress has been associated with male infertility. The …
[HTML][HTML] Bioactive Compounds Protect Mammalian Reproductive Cells from Xenobiotics and Heat Stress-Induced Oxidative Distress via Nrf2 Signaling Activation: A …
Oxidative stress occurs when there is an imbalance between the production of reactive
oxygen species (ROS) and the body's antioxidant defenses. It poses a significant threat to …
oxygen species (ROS) and the body's antioxidant defenses. It poses a significant threat to …
Exploring Nrf2 as a therapeutic target in testicular dysfunction
Testicular dysfunction, a major contributory factor to infertility, has received a lot of attention
over the recent years. Several studies have linked abnormal sperm function and morphology …
over the recent years. Several studies have linked abnormal sperm function and morphology …
[HTML][HTML] Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight
T Hussain, M Kandeel, E Metwally, G Murtaza… - Frontiers in …, 2023 - frontiersin.org
Male infertility is a widely debated issue that affects males globally. There are several
mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with …
mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with …
Endogenous and exogenous antioxidants as a tool to ameliorate male infertility induced by reactive oxygen species
Significance: Antioxidants are essential for the maintenance of cellular redox
homeodynamics in the male reproductive tract, playing a key role in fertilizing potential …
homeodynamics in the male reproductive tract, playing a key role in fertilizing potential …
Reactive oxygen, nitrogen, and sulfur species in human male fertility. A crossroad of cellular signaling and pathology
Infertility is a significant global health problem that currently affects one of six couples in
reproductive age. The quality of male reproductive cells dramatically decreased over the last …
reproductive age. The quality of male reproductive cells dramatically decreased over the last …
Mechanisms of male infertility: role of antioxidants
SA Sheweita, AM Tilmisany… - Current drug …, 2005 - ingentaconnect.com
Defective sperm function is the most common cause of infertility, and until recently, was
difficult to evaluate and treat. Mammalian spermatozoa membranes are rich in poly …
difficult to evaluate and treat. Mammalian spermatozoa membranes are rich in poly …
Effects of Reactive Oxygen and Nitrogen Species on Male Fertility
E Muñoz, F Fuentes, R Felmer, ME Arias… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: In recent decades, male fertility has been severely reduced worldwide. The
causes underlying this decline are multifactorial, and include, among others, genetic …
causes underlying this decline are multifactorial, and include, among others, genetic …
[HTML][HTML] Sperm redox biology challenges the role of antioxidants as a treatment for male factor infertility
E Caroppo, M Dattilo - F&S Reviews, 2022 - Elsevier
In spite of inconclusive or negative outcomes from clinical studies, oral antioxidants are still
largely prescribed to infertile men to improve sperm motility and/or reduce sperm DNA …
largely prescribed to infertile men to improve sperm motility and/or reduce sperm DNA …