Methyl-accepting chemotaxis proteins: a core sensing element in prokaryotes and archaea

AIM Salah Ud-Din, A Roujeinikova - Cellular and Molecular Life Sciences, 2017 - Springer
Chemotaxis is the directed motility by means of which microbes sense chemical cues and
relocate towards more favorable environments. Methyl-accepting chemotaxis proteins …

Evolutionary genomics reveals conserved structural determinants of signaling and adaptation in microbial chemoreceptors

RP Alexander, IB Zhulin - Proceedings of the National …, 2007 - National Acad Sciences
As an important model for transmembrane signaling, methyl-accepting chemotaxis proteins
(MCPs) have been extensively studied by using genetic, biochemical, and structural …

Sensing of environmental signals: classification of chemoreceptors according to the size of their ligand binding regions

J Lacal, C García‐Fontana… - Environmental …, 2010 - Wiley Online Library
Central to the different forms of taxis are methyl‐accepting chemotaxis proteins (MCPs). The
increasing number of genome sequences reveals that MCPs differ enormously in sequence …

Evolutionary Conservation of Methyl-Accepting Chemotaxis Protein Location in Bacteria andArchaea

JE Gestwicki, AC Lamanna, RM Harshey… - Journal of …, 2000 - Am Soc Microbiol
The methyl-accepting chemotaxis proteins (MCPs) are concentrated at the cell poles in an
evolutionarily diverse panel of bacteria and an archeon. In elongated cells, the MCPs are …

Structural basis for amino-acid recognition and transmembrane signalling by tandem Per–Arnt–Sim (tandem PAS) chemoreceptor sensory domains

YC Liu, MA Machuca, SA Beckham… - … Section D: Biological …, 2015 - scripts.iucr.org
Chemotaxis, mediated by methyl-accepting chemotaxis protein (MCP) receptors, plays an
important role in the ecology of bacterial populations. This paper presents the first …

Reconstitution of the bacterial chemotaxis signal transduction system from purified components

EG Ninfa, A Stock, S Mowbray, J Stock - Journal of Biological Chemistry, 1991 - ASBMB
In bacterial chemotaxis, transmembrane receptor proteins detect attractants and repellents
in the medium and send intracellular signals that control motility. The cytoplasmic proteins …

Adaptation in bacterial chemotaxis: CheB-dependent modification permits additional methylations of sensory transducer proteins

MR Kehry, FW Dahlquist - Cell, 1982 - cell.com
Sensory transduction in E. coli consists of two phases, excitation and adaptation, both of
which involve the methyl-accepting chemotaxis proteins (MCPs). These molecules relay …

Universal architecture of bacterial chemoreceptor arrays

A Briegel, DR Ortega, EI Tocheva… - Proceedings of the …, 2009 - National Acad Sciences
Chemoreceptors are key components of the high-performance signal transduction system
that controls bacterial chemotaxis. Chemoreceptors are typically localized in a cluster at the …

Collaborative signaling by mixed chemoreceptor teams in Escherichia coli

P Ames, CA Studdert, RH Reiser… - Proceedings of the …, 2002 - National Acad Sciences
Chemoreceptors of the methyl-accepting chemotaxis protein family form clusters, typically at
the cell pole (s), in both Bacteria and Archaea. To elucidate the architecture and signaling …

Posttranslational processing of methyl-accepting chemotaxis proteins in Escherichia coli

D Sherris, JS Parkinson - Proceedings of the National …, 1981 - National Acad Sciences
Methyl-accepting chemotaxis proteins (MCPs) of Escherichia coli undergo changes in
methylation state in response to chemical stimuli. The addition of methyl groups to MCP is …