Protein lysine lactylation (Kla) is a novel protein acylation reported in recent years, which
plays an important role in the development of several diseases with pathologically elevated …

Background The aim of study was to observe the effect of increased lactate levels during
high-intensity interval training (HIIT) on protein lactylation, identify the target protein, and …

Although studies have proven that high-intensity interval training (HIIT) shows a comparable
effect to moderate-intensity continuous training (MICT) on reducing body fat, especially …

For decades, lactate has been considered a byproduct of glycolysis. The lactate shuttle
hypothesis shifted the lactate paradigm, demonstrating that lactate not only plays important …

Recovery from exercise refers to the period between the end of a bout of exercise and the
subsequent return to a resting or recovered state. It is a dynamic period in which many …

Abstract Background High-intensity Interval Training (HIIT) is a time-efficient form of exercise
and has gained popularity in recent years. However, at molecular level, the understanding …

Lactate has diverse roles in the brain at the molecular and behavioral levels under
physiological and pathophysiological conditions. This study investigates whether lysine …

Cancer cells tend to utilize aerobic glycolysis to generate energy and metabolites; the end
product of aerobic glycolysis is lactate, which promotes lysine lactylation (Kla). Kla is a newly …

Metabolites play important roles in numerous cell biology processes, such as cell
proliferation, differentiation, stress response, and cell death [1]. Recently, lactate and lactate …

As more is learned about lactate, it acts as both a product and a substrate and functions as a
shuttle system between different cell populations to provide the energy for sustaining tumor …