The cellular response to oxygen deprivation is governed largely by a family of transcription
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular …

Hypoxia induces profound changes in the cellular gene expression profile. The discovery of
a major transcription factor family activated by hypoxia, HIF (hypoxia-inducible factor), and …

The basic helix-loop-helix-Per-ARNT-Sim–proteins hypoxia-inducible factor (HIF)-1α and
HIF-2α are the principal regulators of the hypoxic transcriptional response. Although highly …

Abstract Hypoxia inducible factor (HIF)-1 and HIF-2 are heterodimeric transcription factors
mediating the cellular response to hypoxia. Recent data indicate that not only ubiquitous HIF …

Hypoxia-inducible factor (HIF) is a sequence-specific DNA-binding protein that can promote
or repress the transcription of a broad range of genes that are involved in maintaining …

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that is critical for
hypoxic induction of a number of physiologically important genes. We present evidence that …

Cells experiencing lowered O2 levels (hypoxia) undergo a variety of biological responses in
order to adapt to these unfavorable conditions. The master switch, orchestrating the cellular …

The hypoxia-inducible factors 1α (HIF-1α) and 2α (HIF-2α) have extensive structural
homology and have been identified as key transcription factors responsible for gene …

Hypoxia is a common pathophysiological occurrence with a profound impact on the cellular
transcriptome. The consequences of hypoxia-induced or hypoxia-repressed gene …

Hypoxia‐inducible factor (HIF) is a transcription complex which responds to changes in
oxygen, providing cells with a master regulator that coordinates changes in gene …