A response regulator controls Acinetobacter baumannii virulence by acting as an indole receptor

B Cui, Q Guo, X Li, S Song, M Wang, G Wang… - PNAS …, 2023 - academic.oup.com
Indole is an important signal employed by many bacteria to modulate intraspecies signaling
and interspecies or interkingdom communication. Our recent study revealed that indole …

The cell–cell communication signal indole controls the physiology and interspecies communication of Acinetobacter baumannii

B Cui, X Chen, Q Guo, S Song, M Wang… - Microbiology …, 2022 - Am Soc Microbiol
Many bacteria utilize quorum sensing (QS) to control group behavior in a cell density-
dependent manner. Previous studies have demonstrated that Acinetobacter baumannii …

A response regulator protein with antar domain, AvnR, in Acinetobacter baumannii ATCC 17978 impacts its virulence and amino acid metabolism

PM De Silva, R Patidar, CI Graham… - …, 2020 - microbiologyresearch.org
Acinetobacter baumannii, a Gram-negative coccobacillus, is notorious for its involvement in
opportunistic infections around the world. Its resistance to antibiotics makes treatment of …

A Global Virulence Regulator in Acinetobacter baumannii and Its Control of the Phenylacetic Acid Catabolic Pathway

GM Cerqueira, X Kostoulias, C Khoo… - The Journal of …, 2014 - academic.oup.com
Background. Acinetobacter baumannii is one of the most notorious hospital-acquired
pathogens, and novel treatment strategies are desperately required. Two-component …

Indole: a novel signaling molecule and its applications

R Pandey, KV Swamy, MB Khetmalas - 2013 - nopr.niscpr.res.in
A variety of intercellular signal molecules, such as, the most studied N-acyl-
homoserinelactones (AHLs) in Gram-negative bacteria, autoinducer (AI-2) in both Gram …

The abaI/abaR Quorum Sensing System Effects on Pathogenicity in Acinetobacter baumannii

X Sun, Z Ni, J Tang, Y Ding, X Wang, F Li - Frontiers in Microbiology, 2021 - frontiersin.org
Acinetobacter baumannii is a Gram-negative pathogen that has emerged as one of the most
troublesome pathogens for healthcare institutions globally. Bacterial quorum sensing (QS) is …

Joint transcriptional control of virulence and resistance to antibiotic and environmental stress in Acinetobacter baumannii

MJ Gebhardt, LA Gallagher, RK Jacobson… - MBio, 2015 - Am Soc Microbiol
The increasing emergence of antibiotic-resistant bacterial pathogens represents a serious
risk to human health and the entire health care system. Many currently circulating strains of …

Transcriptional regulation of the iac locus from Acinetobacter baumannii by the phytohormone indole-3-acetic acid

HY Shu, LC Lin, TK Lin, HP Chen, HH Yang… - Antonie Van …, 2015 - Springer
The iac locus is involved in indole-3-acetic acid (IAA) catabolism in Acinetobacter
baumannii. Nine structural genes of iac are transcribed in the same direction, whereas iacR …

Signal Transduction Proteins in Acinetobacter baumannii: Role in Antibiotic Resistance, Virulence, and Potential as Drug Targets

PM De Silva, A Kumar - Frontiers in microbiology, 2019 - frontiersin.org
Acinetobacter baumannii is a notorious pathogen in health care settings around the world,
primarily due to high resistance to antibiotics. A. baumannii also shows an impressive …

Evidence for Rho-dependent control of a virulence switch in Acinetobacter baumannii

M Pérez-Varela, R Singh, JM Colquhoun, OG Starich… - Mbio, 2024 - Am Soc Microbiol
Acinetobacter baumannii strain AB5075 is able to interconvert at high frequency between
virulent cells that form opaque colonies (VIR-O) and avirulent cells that form translucent …