Neonates have an immature immune system, which cannot adequately protect against
infectious diseases. Early in life, immune protection is accomplished by maternal antibodies …

Many serious infectious diseases occur early in life; efficacious vaccination of neonates has
been a longstanding goal in both human and veterinary medicine. Efforts to immunize in the …

Infants are born with immature immune systems, making it difficult for them to effectively
respond to the infectious pathogens encountered shortly after birth. Maternal antibody is …

The inhibition of vaccination by maternal antibodies is a widely observed phenomenon in
human and veterinary medicine. Maternal antibodies are known to suppress the B-cell …

Several mechanisms have been suggested as mediating the inhibitory influence of maternal
antibodies (MatAb) on infant responses. This inhibition is B cell determinant-specific …

Presence of maternally-derived antibodies at time of immunization is known to often interfere
with active infant immunization, although with variable degrees of clinical significance. In …

With birth, the newborn is transferred from a quasi-sterile environment to the outside world.
At this time, the neonatal immune system is inexperienced and continuously subject to a …

The transfer of maternal antibodies to the offspring and their inhibitory effects on active infant
immunization is an important factor hampering the use of certain vaccines, such as measles …

Maternal antibodies (MatAbs) protect offspring from infections but limit their responses to
vaccination. The mechanisms of this inhibition are still debated. Using murine early-life …

Neonates are born with an immature immune system and rely on the transfer of immunity
from their mothers. Maternal antibodies are transferred via the placenta and breast milk …