Thoracic aortic disease (TAD) is often silent until a life-threatening complication occurs.
However, genetic information can inform both identification and treatment at an early stage …

Thoracic aortic diseases, whether sporadic or due to a genetic disorder such as Marfan
syndrome, lack effective medical therapies, with limited translation of treatments that are …

Human induced pluripotent stem cell (iPSC) platforms are valuable for biomedical and
pharmaceutical research by providing tissue-specific human cells that retain patients' …

Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …

Personalized regenerative medicine and biomedical research have been galvanized and
revolutionized by human pluripotent stem cells in combination with recent advances in …

Rare cardiovascular diseases (RCDs) refer to those cardiovascular diseases that display a
low prevalence as well as morbidity. Due to the vast variety of underlying genetic mutations …

Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human
physiology and disease at the cellular level. They also have the potential to be leveraged in …

Vascular disorders are complex diseases with high morbidity and mortality. Among them, the
dilated macrovascular diseases (MVD), such as aortic aneurysm and aortic dissection, have …

The available evidence demonstrating improvement in myocardial function following
transplantation of autologous bone marrow–derived stem/progenitor cells, in both preclinical …

Induced pluripotent stem cells (iPSCs) offer an effective platform for studies of human
physiology and have revealed new possibilities for disease modeling at the cellular level …