Human visceral leishmaniasis (VL) results in a severe and potentially fatal systemic disease,
accompanied by cellular immune depression. The production of IL‐10 correlates with …

To determine the in vivo role of IL‐12 in the development of protective immunity in visceral
leishmaniasis caused by Leishmania donovani, we examined the course of L. donovani …

IL‐12 plays a key role in stimulating both innate and antigen‐specific immune responses
against a number of intracellular pathogens. A neutralizing anti‐IL‐12 monoclonal antibody …

Abstract Treatment with interleukin-12 (IL-12) induces leishmanicidal activity in experimental
Leishmania donovani infection; therefore, BALB/c mice were injected with anti-IL-12 …

A comparison of the growth of Leishmania mexicana in IL‐4–/–, IL‐4Rα–/–and wild‐type
BALB/c mice demonstrated a disease exacerbative role for IL‐13 as well as IL‐4. Thus …

Mice with homologous disruption of the gene coding for either the p35 subunit or the p40
subunit of interleukin‐12 (IL‐12) and derived from a strain genetically resistant to infection …

Interleukin-12 (IL-12)-deficient mice derived from a strain genetically resistant to infection
with Leishmania major were recently shown to be susceptible toward this parasite …

In established Leishmania donovani visceral infection in normal mice, anti-interleukin (IL)-10
receptor (IL-10R) monoclonal antibody (MAb) treatment induced intracellular parasite killing …

The roles of IL-10 and IL-4 receptor signaling were evaluated in a murine model of
Leishmania major infection. In previous studies the L. major substrain LV39 caused …

IL-9 is a cytokine produced by Th2 cells, induced during Leishmania major infection.
Because the role of IL-9 in leishmaniasis is currently unknown, IL-9-deficient mice were …