IL‐10 mediates susceptibility to Leishmania donovani infection
ML Murphy, U Wille, EN Villegas… - European journal of …, 2001 - Wiley Online Library
Human visceral leishmaniasis (VL) results in a severe and potentially fatal systemic disease,
accompanied by cellular immune depression. The production of IL‐10 correlates with …
accompanied by cellular immune depression. The production of IL‐10 correlates with …
IL‐12 gene‐deficient C57BL / 6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathology
AR Satoskar, S Rodig, SR Telford III… - European journal of …, 2000 - Wiley Online Library
To determine the in vivo role of IL‐12 in the development of protective immunity in visceral
leishmaniasis caused by Leishmania donovani, we examined the course of L. donovani …
leishmaniasis caused by Leishmania donovani, we examined the course of L. donovani …
Neutralization of IL‐12 demonstrates the existence of discrete organ‐specific phases in the control of Leishmania donovani
CR Engwerda, ML Murphy, SEJ Cotterell… - European journal of …, 1998 - Wiley Online Library
IL‐12 plays a key role in stimulating both innate and antigen‐specific immune responses
against a number of intracellular pathogens. A neutralizing anti‐IL‐12 monoclonal antibody …
against a number of intracellular pathogens. A neutralizing anti‐IL‐12 monoclonal antibody …
Endogenous interleukin-12 regulates acquired resistance in experimental visceral leishmaniasis
HW Murray - The Journal of infectious diseases, 1997 - academic.oup.com
Abstract Treatment with interleukin-12 (IL-12) induces leishmanicidal activity in experimental
Leishmania donovani infection; therefore, BALB/c mice were injected with anti-IL-12 …
Leishmania donovani infection; therefore, BALB/c mice were injected with anti-IL-12 …
An essential role for IL‐13 in maintaining a non‐healing response following Leishmania mexicana infection
J Alexander, F Brombacher… - European journal of …, 2002 - Wiley Online Library
A comparison of the growth of Leishmania mexicana in IL‐4–/–, IL‐4Rα–/–and wild‐type
BALB/c mice demonstrated a disease exacerbative role for IL‐13 as well as IL‐4. Thus …
BALB/c mice demonstrated a disease exacerbative role for IL‐13 as well as IL‐4. Thus …
Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response
F Mattner, J Magram, J Ferrante… - European journal of …, 1996 - Wiley Online Library
Mice with homologous disruption of the gene coding for either the p35 subunit or the p40
subunit of interleukin‐12 (IL‐12) and derived from a strain genetically resistant to infection …
subunit of interleukin‐12 (IL‐12) and derived from a strain genetically resistant to infection …
Interleukin-12 is indispensable for protective immunity against Leishmania major
F Mattner, K Di Padova, G Alber - Infection and immunity, 1997 - Am Soc Microbiol
Interleukin-12 (IL-12)-deficient mice derived from a strain genetically resistant to infection
with Leishmania major were recently shown to be susceptible toward this parasite …
with Leishmania major were recently shown to be susceptible toward this parasite …
Determinants of response to interleukin-10 receptor blockade immunotherapy in experimental visceral leishmaniasis
HW Murray, M Andre L, CM Lu… - The Journal of …, 2003 - academic.oup.com
In established Leishmania donovani visceral infection in normal mice, anti-interleukin (IL)-10
receptor (IL-10R) monoclonal antibody (MAb) treatment induced intracellular parasite killing …
receptor (IL-10R) monoclonal antibody (MAb) treatment induced intracellular parasite killing …
The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major
N Noben-Trauth, R Lira, H Nagase… - The Journal of …, 2003 - journals.aai.org
The roles of IL-10 and IL-4 receptor signaling were evaluated in a murine model of
Leishmania major infection. In previous studies the L. major substrain LV39 caused …
Leishmania major infection. In previous studies the L. major substrain LV39 caused …
IL-9 is a susceptibility factor in Leishmania major infection by promoting detrimental Th2/type 2 responses
B Arendse, J Van Snick… - The Journal of Immunology, 2005 - journals.aai.org
IL-9 is a cytokine produced by Th2 cells, induced during Leishmania major infection.
Because the role of IL-9 in leishmaniasis is currently unknown, IL-9-deficient mice were …
Because the role of IL-9 in leishmaniasis is currently unknown, IL-9-deficient mice were …