[PDF][PDF] CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

THO Nguyen, LC Rowntree, J Petersen, BY Chua… - Immunity, 2021 - cell.com
To better understand primary and recall T cell responses during coronavirus disease 2019
(COVID-19), it is important to examine unmanipulated severe acute respiratory syndrome …

[PDF][PDF] CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses

KE Lineburg, EJ Grant, S Swaminathan… - Immunity, 2021 - cell.com
Efforts are being made worldwide to understand the immune response to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the coronavirus …

[HTML][HTML] SARS-CoV-2–specific CD8+ T cell responses in convalescent COVID-19 individuals

H Kared, AD Redd, EM Bloch, TS Bonny… - The Journal of …, 2021 - Am Soc Clin Investig
Characterization of the T cell response in individuals who recover from severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical to understanding its …

SARS-CoV-2 epitope–specific CD4+ memory T cell responses across COVID-19 disease severity and antibody durability

RW Nelson, Y Chen, OL Venezia, RM Majerus… - Science …, 2022 - science.org
CD4+ T cells are central to long-term immunity against viruses through the functions of T
helper 1 (TH1) and T follicular helper (TFH) cell subsets. To better understand the role of …

[PDF][PDF] SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T cell receptors

AS Shomuradova, MS Vagida, SA Sheetikov… - Immunity, 2020 - cell.com
Understanding the hallmarks of the immune response to SARS-CoV-2 is critical for fighting
the COVID-19 pandemic. We assessed antibody and T cell reactivity in convalescent COVID …

[HTML][HTML] Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals

S Mahajan, V Kode, K Bhojak, C Karunakaran, K Lee… - Scientific reports, 2021 - nature.com
The COVID-19 pandemic has revealed a range of disease phenotypes in infected patients
with asymptomatic, mild, or severe clinical outcomes, but the mechanisms that determine …

[PDF][PDF] Unbiased screens show CD8+ T cells of COVID-19 patients recognize shared epitopes in SARS-CoV-2 that largely reside outside the spike protein

AP Ferretti, T Kula, Y Wang, DMV Nguyen… - Immunity, 2020 - cell.com
Developing effective strategies to prevent or treat coronavirus disease 2019 (COVID-19)
requires understanding the natural immune response to severe acute respiratory syndrome …

Identification of SARS-CoV-2 nucleocapsid and spike T-cell epitopes for assessing T-cell immunity

E Lee, K Sandgren, G Duette, VV Stylianou… - Journal of …, 2021 - Am Soc Microbiol
Developing optimal T-cell response assays to severe acute respiratory syndrome
coronavirus type 2 (SARS-CoV-2) is critical for measuring the duration of immunity to this …

[HTML][HTML] Immunogenic T cell epitopes of SARS-CoV-2 are recognized by circulating memory and naïve CD8 T cells of unexposed individuals

I Quiros-Fernandez, M Poorebrahim, E Fakhr… - …, 2021 - thelancet.com
Background Recent studies have provided evidence of T cell reactivity to Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in significant numbers of non-infected …

[PDF][PDF] Profiling CD8+ T cell epitopes of COVID-19 convalescents reveals reduced cellular immune responses to SARS-CoV-2 variants

H Zhang, S Deng, L Ren, P Zheng, X Hu, T Jin, X Tan - Cell reports, 2021 - cell.com
Cellular immunity is important in determining the disease severity of COVID-19 patients.
However, current understanding of SARS-CoV-2 epitopes mediating cellular immunity is …