Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently
needed. We developed a robust and simple, PCR-based host-blood transcriptomic …

Background A rapid, blood-based triage test that allows targeted investigation for
tuberculosis at the point of care could shorten the time to tuberculosis treatment and reduce …

HIV-infected individuals are at high risk of tuberculosis disease and those with prior
tuberculosis episodes are at even higher risk of disease recurrence. A non-sputum …

Background Blood transcriptional signatures are candidates for non-sputum triage or
confirmatory tests of tuberculosis. Prospective head-to-head comparisons of their diagnostic …

Introduction Host blood transcriptomic biomarkers have potential as rapid point-of-care
triage, diagnostic, and predictive tests for Tuberculosis disease. We aimed to summarise the …

Biomarkers for tuberculosis treatment outcome will assist in guiding individualized treatment
and evaluation of new therapies. To identify candidate biomarkers, RNA sequencing of …

There is an urgent need for new tools to combat the ongoing tuberculosis (TB) pandemic.
Gene expression profiles based on blood signatures have proved useful in identifying genes …

Background Multiple blood transcriptional signatures have been proposed for identification
of active and incipient tuberculosis. We aimed to compare the performance of systematically …

Tuberculosis (TB) is a leading cause of morbidity and mortality from a single infectious
agent, despite being preventable and curable. Early and accurate diagnosis of active TB is …

Background A nonsputum blood test capable of predicting progression of healthy individuals
to active tuberculosis (TB) before clinical symptoms manifest would allow targeted treatment …