Background Highly parallel,'second generation'sequencing technologies have rapidly
expanded the number of bacterial whole genome sequences available for study, permitting …

Background Genome sequences, now available for most pathogens, hold promise for the
rational design of new therapies. However, biological resources for genome-scale …

Rapid low-cost whole-genome sequencing (WGS) is revolutionizing microbiology; however,
complementary advances in accessible, reproducible, and rapid analysis techniques are …

The biologic role of a majority of the Neisseria meningitidis 2100 predicted coding regions is
still to be assigned or experimentally confirmed. Determining the phenotypic effect of gene …

Meningococcal disease remains an important cause of morbidity and death worldwide
despite the development and increasing implementation of effective vaccines. Elimination of …

Neisseria meningitidis is a leading cause of infectious childhood mortality worldwide. Most
research efforts have hitherto focused on disease isolates belonging to only a few …

Abstract Background The genus Neisseria contains two important yet very different
pathogens, N. meningitidis and N. gonorrhoeae, in addition to non-pathogenic species, of …

Despite being a well-established research method, the use of whole-genome sequencing
(WGS) for routine molecular typing and pathogen characterization remains a substantial …

The study of genetic and phenotypic variation is fundamental for understanding the
dynamics of bacterial genome evolution and untangling the evolution and epidemiology of …

Genome-Wide Association Studies (GWAS) in microbial organisms have the potential to
vastly improve the way we understand, manage, and treat infectious diseases. Yet, microbial …