[HTML][HTML] DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
M Okano, DW Bell, DA Haber, E Li - Cell, 1999 - cell.com
The establishment of DNA methylation patterns requires de novo methylation that occurs
predominantly during early development and gametogenesis in mice. Here we demonstrate …
predominantly during early development and gametogenesis in mice. Here we demonstrate …
Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b
T Chen, Y Ueda, JE Dodge, Z Wang… - Molecular and cellular …, 2003 - Am Soc Microbiol
We have previously shown that the DNA methyltransferases Dnmt3a and Dnmt3b carry out
de novo methylation of the mouse genome during early postimplantation development and …
de novo methylation of the mouse genome during early postimplantation development and …
DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction
I Suetake, F Shinozaki, J Miyagawa… - Journal of Biological …, 2004 - ASBMB
In mammals, the resetting of DNA methylation patterns in early embryos and germ cells is
crucial for development. Two DNA methyltransferases, Dnmt3a and Dnmt3b, are …
crucial for development. Two DNA methyltransferases, Dnmt3a and Dnmt3b, are …
[HTML][HTML] Loss of the maternal imprint in Dnmt3Lmat−/− mice leads to a differentiation defect in the extraembryonic tissue
DNA methylation of the genome is essential for mammalian development and plays crucial
roles in a variety of biological processes including genomic imprinting. Although the DNA …
roles in a variety of biological processes including genomic imprinting. Although the DNA …
Coordinate regulation of DNA methyltransferase expression during oogenesis
D Lucifero, S La Salle, D Bourc'his, J Martel… - BMC developmental …, 2007 - Springer
Background Normal mammalian development requires the action of DNA
methyltransferases (DNMTs) for the establishment and maintenance of DNA methylation …
methyltransferases (DNMTs) for the establishment and maintenance of DNA methylation …
Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions
S Takebayashi, T Tamura, C Matsuoka… - Molecular and cellular …, 2007 - Taylor & Francis
DNA methyltransferase 1 (DNMT1) plays an important role in the inheritance of genomic
DNA methylation, which is coupled to the DNA replication process. Early embryonic lethality …
DNA methylation, which is coupled to the DNA replication process. Early embryonic lethality …
Dynamics of Dnmt1 methyltransferase expression and intracellular localization during oogenesis and preimplantation development
S Ratnam, C Mertineit, F Ding, CY Howell… - Developmental …, 2002 - Elsevier
The imprinting of mammalian genes depends on the maintenance of DNA methylation
patterns during pre-and postimplantation development. Dnmt1o is a variant form of the …
patterns during pre-and postimplantation development. Dnmt1o is a variant form of the …
Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene
Maintenance of genomic methylation patterns in mammalian somatic cells depends on DNA
methyltransferase-1 (Dnmt1). Mouse oocytes and preimplantation embryos lack Dnmt1 but …
methyltransferase-1 (Dnmt1). Mouse oocytes and preimplantation embryos lack Dnmt1 but …
The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a
F Chedin, MR Lieber, CL Hsieh - Proceedings of the …, 2002 - National Acad Sciences
Dnmt3L is required for the establishment of maternal methylation imprints at imprinting
centers (ICs). Dnmt3L, however, lacks the conserved catalytic domain common to DNA …
centers (ICs). Dnmt3L, however, lacks the conserved catalytic domain common to DNA …
[HTML][HTML] Stage-and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis
DNA methylation is essential for development. Two DNA methyltransferases, Dnmt3a and
Dnmt3b, contribute to the creation of DNA methylation patterns in embryos. We …
Dnmt3b, contribute to the creation of DNA methylation patterns in embryos. We …