[HTML][HTML] Phage cocktail development for bacteriophage therapy: toward improving spectrum of activity breadth and depth

ST Abedon, KM Danis-Wlodarczyk, DJ Wozniak - Pharmaceuticals, 2021 - mdpi.com
Phage therapy is the use of bacterial viruses as antibacterial agents. A primary
consideration for commercial development of phages for phage therapy is the number of …

Designing phage therapeutics

LD Goodridge - Current pharmaceutical biotechnology, 2010 - ingentaconnect.com
Phage therapy is the application of phages to bodies, substances, or environments to effect
the biocontrol of pathogenic or nuisance bacteria. To be effective, phages, minimally, must …

[HTML][HTML] Phage therapy faces evolutionary challenges

C Torres-Barceló - Viruses, 2018 - mdpi.com
Antibiotic resistance evolution in bacteria indicates that one of the challenges faced by
phage therapy is that, sooner or later, bacteria will evolve resistance to phages. Evidently …

Drivers and consequences of bacteriophage host range

D Holtappels, P Alfenas-Zerbini… - FEMS Microbiology …, 2023 - academic.oup.com
Bacteriophages are obligate parasites of bacteria characterized by the breadth of hosts that
they can infect. This “host range” depends on the genotypes and morphologies of the phage …

Phage therapy pharmacology: phage cocktails

BK Chan, ST Abedon - Advances in applied microbiology, 2012 - Elsevier
Phage therapy is the clinical or veterinary application of bacterial viruses (bacteriophages)
as antibacterial “drugs.” More generally, phages can be used as biocontrol agents against …

[HTML][HTML] Developing phage therapy that overcomes the evolution of bacterial resistance

A Oromí-Bosch, JD Antani… - Annual Review of Virology, 2023 - annualreviews.org
The global rise of antibiotic resistance in bacterial pathogens and the waning efficacy of
antibiotics urge consideration of alternative antimicrobial strategies. Phage therapy is a …

Phage therapy: awakening a sleeping giant

DR Roach, L Debarbieux - Emerging Topics in Life Sciences, 2017 - portlandpress.com
For a century, bacterial viruses called bacteriophages have been exploited as natural
antibacterial agents. However, their medicinal potential has not yet been exploited due to …

[HTML][HTML] Systematic analysis of putative phage-phage interactions on minimum-sized phage cocktails

F Molina, M Menor-Flores, L Fernández… - Scientific Reports, 2022 - nature.com
The application of bacteriophages as antibacterial agents has many benefits in the “post-
antibiotic age”. To increase the number of successfully targeted bacterial strains, phage …

[HTML][HTML] Phage therapy: From biological mechanisms to future directions

SA Strathdee, GF Hatfull, VK Mutalik, RT Schooley - Cell, 2023 - cell.com
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research,
the natural predators of bacteria discovered over 100 years ago. In order to use phages …

Reinventing phage therapy: are the parts greater than the sum?

VA Fischetti, D Nelson, R Schuch - Nature biotechnology, 2006 - nature.com
Reinventing phage therapy: are the parts greater than the sum? | Nature Biotechnology
Skip to main content Thank you for visiting nature.com. You are using a browser version …