Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

Nuclear receptors have generated substantial interest in the past decade as potential
therapeutic targets for the treatment of neurodegenerative disorders. Despite years of effort …

Neurodegenerative diseases are characterized by a progressive loss of neurons that leads
to a broad range of disabilities, including severe cognitive decline and motor impairment, for …

Chronic inflammation is associated with many neurodegenerative diseases, including
multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Increasing evidence that …

Nuclear receptors (NRs) are a family of ligand‐modulated transcription factors with
significant therapeutic relevance from metabolic disorders and inflammation to cancer …

Alzheimer's disease (AD) is characterized by an extensive accumulation of amyloid-β (Aβ)
peptide, which triggers a set of deleterious processes, including synaptic dysfunction …

Nuclear receptor modulation enables pharmacological control of gene expression thus
rendering the 48 human nuclear receptors as attractive targets for drug discovery. Several …

Hippocampal neurogenesis, the process by which new neurons are born and develop into
the host circuitry, begins during embryonic development and persists throughout adulthood …

Introduction: Alzheimer's disease (AD) is characterized by the accumulation and extensive
deposition of amyloid β (Aβ) in the parenchyma of the brain. This accumulation of amyloid is …

After 15 years of research into Alzheimer's disease (AD) therapeutics, including billions of
US dollars provided by federal agencies, pharmaceutical companies, and private …