Background and Objectives: Nephroprotective effect of statins is still controversial. The aim
of this study was to investigate the possible hemin-like nephroprotective effect of …

The development of diabetic nephropathy (DN) relays mainly on control of blood glucose
and restrains hyperglycemic-induced oxidative stress. Hence, the effect administration of …

The present study aims to study the possible renal protective effect of simvastatin in the
development and progression of type 2 diabetic nephropathy. A rat model of T2DN was …

Purpose Persistent hyperglycemia lead towards depletion of hydrogen sulfide (H2S)
resulting in generation of oxidative stress and diabetic nephropathy. The aim of the current …

Aim Diabetic nephropathy is the leading cause of end stage renal disease in developed
countries throughout the world. The imbalance between the production of reactive oxygen …

Background Diabetic nephropathy is the leading cause of kidney failure worldwide. NADPH
oxidase 4 (NOX4) is an obvious cause for reactive oxygen species production in the kidney …

Atorvastatin (AT) has been alternatively used for managing diabetic complications in clinic.
However, AT-related therapeutic potentiality remains relatively unexplored, especially in …

Statins are HMG-CoA reductase inhibitors with lipid-lowering effect and commonly used to
reduce cardiovascular risk in diabetic patients. The present study investigates the …

OBJECTIVE: Though increasing evidences showed that statins had potential benefits to
diabetic kidney disease (DKD), its mechanism has not been completely elucidated yet. The …

BACKGROUND Clinical trials show potent renoprotective effects of pitavastatin (PTV),
although the precise mechanism for these renoprotective effects is not fully clarified. The aim …