Cocaine addiction is characterized by an impaired ability to develop adaptive behaviors that
can compete with cocaine seeking, implying a deficit in the ability to induce plasticity in …

Addictive drugs hijack mechanisms of learning and memory that normally underlie
reinforcement of natural rewards and induce synaptic plasticity of glutamatergic transmission …

Cocaine addiction remains without an effective pharmacotherapy and is characterized by an
inability of addicts to inhibit relapse to drug use. Vulnerability to relapse arises from an …

The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely
elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and …

Exposure to drugs of abuse can result in a loss of control over both drug-and nondrug-
related actions by accelerating the transition from goal-directed to habitual control, an effect …

Plasticity of glutamatergic synapses is a fundamental mechanism through which experience
changes neural function to impact future behavior. In animal models of addiction …

Addiction is a chronic relapsing disorder hypothesized to be produced by drug-induced
plasticity that renders individuals vulnerable to craving-inducing stimuli such as re-exposure …

Cocaine produces a persistent reduction in cystine–glutamate exchange via system xc− in
the nucleus accumbens that may contribute to pathological glutamate signaling linked to …

The neuroadaptation theory of addiction suggests that, similar to the development of most
memories, exposure to drugs of abuse induces adaptive molecular and cellular changes in …

A growing body of evidence indicates that repeated exposure to cocaine leads to profound
changes in glutamate transmission in limbic nuclei, particularly the nucleus accumbens. This …