Safety of combining radiotherapy with immune-checkpoint inhibition
Immune-checkpoint inhibitors targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4),
programmed cell death protein 1 (PD-1), or programmed cell death 1 ligand 1 (PD-L1) have …
programmed cell death protein 1 (PD-1), or programmed cell death 1 ligand 1 (PD-L1) have …
Radiotherapy and checkpoint inhibitors: a winning new combination?
EC Ko, SC Formenti - Therapeutic advances in medical …, 2018 - journals.sagepub.com
Immune checkpoint blockade has recently emerged as an important therapeutic approach to
the management of malignancies across multiple disease settings. Concomitantly, there has …
the management of malignancies across multiple disease settings. Concomitantly, there has …
Toxicity in combination immune checkpoint inhibitor and radiation therapy: A systematic review and meta-analysis
Background and purpose Immune checkpoint inhibitor with radiation therapy (ICI+ RT) is
under investigation for improved patient outcome, so we performed a systematic …
under investigation for improved patient outcome, so we performed a systematic …
Combination of radiotherapy and immune checkpoint inhibitors
The ability of ionizing radiation to cause cell death and inflammatory reactions has been
known since the beginning of its therapeutic use in oncology. However, only recently this …
known since the beginning of its therapeutic use in oncology. However, only recently this …
Radiotherapy: changing the game in immunotherapy
S Demaria, CN Coleman, SC Formenti - Trends in cancer, 2016 - cell.com
Immune checkpoint inhibitors (ICI) are effective in cancer treatment. A pre-existing immune
response demonstrated by significant pretreatment tumor lymphocytic infiltration is a …
response demonstrated by significant pretreatment tumor lymphocytic infiltration is a …
Toward precision radiotherapy for use with immune checkpoint blockers
The first evidence that radiotherapy enhances the efficacy of immune checkpoint blockers
(ICB) was obtained a dozen years ago in a mouse model of metastatic carcinoma refractory …
(ICB) was obtained a dozen years ago in a mouse model of metastatic carcinoma refractory …
Radiotherapy and immunotherapy: open questions and future strategies
KB Pointer, SP Pitroda, RR Weichselbaum - Trends in Cancer, 2022 - cell.com
Immune checkpoint blockade (ICB) improves outcomes for some patients with advanced or
metastatic cancers. Despite demonstrable progress, many patients do not respond to ICB …
metastatic cancers. Despite demonstrable progress, many patients do not respond to ICB …
Multicenter evaluation of the tolerability of combined treatment with PD-1 and CTLA-4 immune checkpoint inhibitors and palliative radiation therapy
Purpose To analyze immune-related adverse events (ir-AEs) in patients treated with
radiation and immune checkpoint blockade. Methods and Materials We retrospectively …
radiation and immune checkpoint blockade. Methods and Materials We retrospectively …
[HTML][HTML] The promise of combining radiation therapy with immunotherapy
JC Jagodinsky, PM Harari, ZS Morris - International Journal of Radiation …, 2020 - Elsevier
The development of immunotherapy in oncology builds upon many years of scientific
investigation into the cellular mechanics underlying interactions between tumor cells and …
investigation into the cellular mechanics underlying interactions between tumor cells and …
Immune checkpoint inhibitor‐based strategies for synergistic cancer therapy
Immune checkpoint blockade therapy (ICBT) targeting checkpoints, such as, cytotoxic T‐
lymphocyte associated protein‐4 (CTLA‐4), programmed death‐1 (PD‐1), or programmed …
lymphocyte associated protein‐4 (CTLA‐4), programmed death‐1 (PD‐1), or programmed …