Deregulation of E3 ubiquitin ligases is intimately implicated in breast cancer pathogenesis
and progression, but the underlying mechanisms still remain elusive. Here we report that …

The E3 ubiquitin ligase ring finger protein 115 (RNF 115) is overexpressed in more than half
of human breast tumors and is implicated in the pathogenesis and progression of breast …

Ring finger protein 144A (RNF144A), a poorly characterized member of the RING-in-
between-RING family of E3 ubiquitin ligases, is an emerging tumor suppressor, but its …

Defects in ubiquitin E3 ligases are implicated in the pathogenesis of several human
diseases, including cancer, because of their central role in the control of diverse signaling …

Abstract Heat-shock protein 5 (HSPA5) is a marker for poor prognosis in breast cancer
patients and has an important role in cancer progression, including promoting drug …

Emerging evidence shows that ring finger protein 144A (RNF 144A), a poorly characterized
member of the Ring‐between‐Ring (RBR) family of E3 ubiquitin ligases, is a potential tumor …

The dysfunction of E3 ubiquitin ligases is important in the pathogenesis of many human
diseases, as they play important roles in multiple cellular processes. In this review, we …

The tumor suppressor P53 plays critical role in preventing cancer. P53 is rarely mutated and
remains functional in luminal-type breast cancer (1). According to current knowledge, wild …

To identify novel oncogenic E3 ubiquitin ligases as anticancer targets, we screened an E3
ubiquitin ligase siRNA library containing siRNA pools against 555 individual E3s using the …

Objective Breast cancer has become the first highest incidence which surpasses lung
cancer as the most commonly diagnosed cancer, and the second highest mortality among …