Cryptic promoters within transposable elements (TEs) can be transcriptionally reactivated in
tumors to create new TE-chimeric transcripts, which can produce immunogenic antigens. We …

Approximately 45% of the human genome is composed of transposable elements (TEs).
Expression of these elements is tightly regulated during normal development. TEs may be …

Profound global loss of DNA methylation is a hallmark of many cancers. One potential
consequence of this is the reactivation of transposable elements (TEs) which could stimulate …

Transposable elements (TEs) represent almost half of the human genome. Historically
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …

Transposable elements (TEs) are an abundant and rich genetic resource of regulatory
sequences,–. Cryptic regulatory elements within TEs can be epigenetically reactivated in …

Transposable elements (TE) are repetitive genomic elements that harbor binding sites for
human transcription factors (TF). A regulatory role for TEs has been suggested in embryonal …

Simple Summary Cancer immunology is a rapidly evolving field. In this context, this review
article has three objectives. First, to explain the genomic origin of tumor antigens and to …

Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but few
have been identified thus far. We therefore developed a proteogenomic approach to enable …

The search for tumor-specific antigens (TSAs) has considerably accelerated during the past
decade due to the improvement of proteogenomic detection methods. This provides new …

Cancer/Testis (CT) genes, normally expressed in germ line cells but also activated in a wide
range of cancer types, often encode antigens that are immunogenic in cancer patients, and …