Pan-cancer analysis identifies tumor-specific antigens derived from transposable elements
Cryptic promoters within transposable elements (TEs) can be transcriptionally reactivated in
tumors to create new TE-chimeric transcripts, which can produce immunogenic antigens. We …
tumors to create new TE-chimeric transcripts, which can produce immunogenic antigens. We …
Transposable element regulation and expression in cancer
EE Grundy, N Diab, KB Chiappinelli - The FEBS journal, 2022 - Wiley Online Library
Approximately 45% of the human genome is composed of transposable elements (TEs).
Expression of these elements is tightly regulated during normal development. TEs may be …
Expression of these elements is tightly regulated during normal development. TEs may be …
Transposable element expression in tumors is associated with immune infiltration and increased antigenicity
Profound global loss of DNA methylation is a hallmark of many cancers. One potential
consequence of this is the reactivation of transposable elements (TEs) which could stimulate …
consequence of this is the reactivation of transposable elements (TEs) which could stimulate …
Towards targeting Transposable elements for cancer therapy
Transposable elements (TEs) represent almost half of the human genome. Historically
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …
Transposable elements drive widespread expression of oncogenes in human cancers
Transposable elements (TEs) are an abundant and rich genetic resource of regulatory
sequences,–. Cryptic regulatory elements within TEs can be epigenetically reactivated in …
sequences,–. Cryptic regulatory elements within TEs can be epigenetically reactivated in …
Transposable elements as tissue-specific enhancers in cancers of endodermal lineage
Transposable elements (TE) are repetitive genomic elements that harbor binding sites for
human transcription factors (TF). A regulatory role for TEs has been suggested in embryonal …
human transcription factors (TF). A regulatory role for TEs has been suggested in embryonal …
The origin and immune recognition of tumor-specific antigens
Simple Summary Cancer immunology is a rapidly evolving field. In this context, this review
article has three objectives. First, to explain the genomic origin of tumor antigens and to …
article has three objectives. First, to explain the genomic origin of tumor antigens and to …
Noncoding regions are the main source of targetable tumor-specific antigens
CM Laumont, K Vincent, L Hesnard… - Science translational …, 2018 - science.org
Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but few
have been identified thus far. We therefore developed a proteogenomic approach to enable …
have been identified thus far. We therefore developed a proteogenomic approach to enable …
A roadmap toward the definition of actionable tumor-specific antigens
R Minati, C Perreault, P Thibault - Frontiers in Immunology, 2020 - frontiersin.org
The search for tumor-specific antigens (TSAs) has considerably accelerated during the past
decade due to the improvement of proteogenomic detection methods. This provides new …
decade due to the improvement of proteogenomic detection methods. This provides new …
Genome-wide analysis of cancer/testis gene expression
O Hofmann, OL Caballero… - Proceedings of the …, 2008 - National Acad Sciences
Cancer/Testis (CT) genes, normally expressed in germ line cells but also activated in a wide
range of cancer types, often encode antigens that are immunogenic in cancer patients, and …
range of cancer types, often encode antigens that are immunogenic in cancer patients, and …