Neonatal encephalopathy is a leading cause of morbidity and mortality worldwide. Although
therapeutic hypothermia (HT) is now standard practice in most neonatal intensive care units …

Objective Melatonin has shown neuroprotective properties in pre-clinical studies of perinatal
asphyxia through antioxidant, anti-apoptotic and anti-inflammatory actions. Studies have …

Hypoxic-ischemic encephalopathy (HIE) is the main cause of long-term neurodevelopmental
morbidity in term born infants worldwide. Melatonin is a hormone with antioxidant and anti …

Hypoxic-ischemic encephalopathy (HIE) is one of the most frequent causes of brain injury in
the newborn. From a pathophysiological standpoint, a complex process takes place at the …

Brain injury related to preterm birth and neonatal asphyxia is a leading cause of childhood
neuromotor and cognitive disabilities. Unfortunately, the strategies to prevent perinatal brain …

Perinatal asphyxia is considered to be one of the major causes of brain neurodegeneration
in full-term newborns. The worst consequence of perinatal asphyxia is neurodegenerative …

Despite treatment with therapeutic hypothermia, almost 50% of infants with neonatal
encephalopathy still have adverse outcomes. Additional treatments are required to …

Objective: Melatonin has been shown to be neuroprotective in animal models. The objective
of this study is to examine the effect of melatonin on clinical, biochemical …

Therapeutic hypothermia is only partially protective for neonatal encephalopathy; there is an
urgent need to develop treatments that augment cooling. Our objective was to assess safety …

The prevention of neurological disabilities following preterm birth remains a major public
health challenge and efforts are still needed to test the neuroprotective properties of …