Perineuronal net dynamics in the pathophysiology of epilepsy

L Chaunsali, BP Tewari, H Sontheimer - Epilepsy Currents, 2021 - journals.sagepub.com
Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) assemblies of
polyanionic chondroitin sulfate proteoglycans, hyaluronan, and tenascins that primarily wrap …

The perineuronal net component of the extracellular matrix in plasticity and epilepsy

PA McRae, BE Porter - Neurochemistry international, 2012 - Elsevier
During development the extracellular matrix (ECM) of the central nervous system (CNS)
facilitates proliferation, migration, and synaptogenesis. In the mature nervous system due to …

Proteolytic remodeling of perineuronal nets: effects on synaptic plasticity and neuronal population dynamics

P Lorenzo Bozzelli, S Alaiyed, E Kim, S Villapol… - Neural …, 2018 - Wiley Online Library
The perineuronal net (PNN) represents a lattice‐like structure that is prominently expressed
along the soma and proximal dendrites of parvalbumin‐(PV‐) positive interneurons in varied …

Perineuronal net degradation in epilepsy

EK Rankin‐Gee, PA McRae, E Baranov, S Rogers… - …, 2015 - Wiley Online Library
Objective We previously reported loss of perineuronal net (PN) immunohistochemical
staining around parvalbumin‐positive interneurons in the hippocampus of rats after an …

[HTML][HTML] The perineuronal 'safety'net? Perineuronal net abnormalities in neurological disorders

TH Wen, DK Binder, IM Ethell… - Frontiers in molecular …, 2018 - frontiersin.org
Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …

[HTML][HTML] Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy

BP Tewari, L Chaunsali, SL Campbell, DC Patel… - Nature …, 2018 - nature.com
Brain tumor patients commonly present with epileptic seizures. We show that tumor-
associated seizures are the consequence of impaired GABAergic inhibition due to an overall …

Casting a wide net: role of perineuronal nets in neural plasticity

BA Sorg, S Berretta, JM Blacktop… - Journal of …, 2016 - Soc Neuroscience
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain
neurons in the CNS during development and control plasticity in the adult CNS. They appear …

Perineuronal nets in brain physiology and disease

D Testa, A Prochiantz, AA Di Nardo - Seminars in cell & developmental …, 2019 - Elsevier
Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular
matrix structures with heterogeneous composition yet specific organization. They typically …

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

JW Fawcett, T Oohashi, T Pizzorusso - Nature Reviews Neuroscience, 2019 - nature.com
Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

[HTML][HTML] Quantitative changes in perineuronal nets in development and posttraumatic condition

N Lipachev, N Arnst, A Melnikova, H Jäälinoja… - Journal of molecular …, 2019 - Springer
Perineuronal net (PNN) is a highly structured portion of the CNS extracellular matrix (ECM)
regulating synaptic plasticity and a range of pathologic conditions including posttraumatic …