Perineuronal net dynamics in the pathophysiology of epilepsy
Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) assemblies of
polyanionic chondroitin sulfate proteoglycans, hyaluronan, and tenascins that primarily wrap …
polyanionic chondroitin sulfate proteoglycans, hyaluronan, and tenascins that primarily wrap …
The perineuronal net component of the extracellular matrix in plasticity and epilepsy
PA McRae, BE Porter - Neurochemistry international, 2012 - Elsevier
During development the extracellular matrix (ECM) of the central nervous system (CNS)
facilitates proliferation, migration, and synaptogenesis. In the mature nervous system due to …
facilitates proliferation, migration, and synaptogenesis. In the mature nervous system due to …
Proteolytic remodeling of perineuronal nets: effects on synaptic plasticity and neuronal population dynamics
P Lorenzo Bozzelli, S Alaiyed, E Kim, S Villapol… - Neural …, 2018 - Wiley Online Library
The perineuronal net (PNN) represents a lattice‐like structure that is prominently expressed
along the soma and proximal dendrites of parvalbumin‐(PV‐) positive interneurons in varied …
along the soma and proximal dendrites of parvalbumin‐(PV‐) positive interneurons in varied …
Perineuronal net degradation in epilepsy
EK Rankin‐Gee, PA McRae, E Baranov, S Rogers… - …, 2015 - Wiley Online Library
Objective We previously reported loss of perineuronal net (PN) immunohistochemical
staining around parvalbumin‐positive interneurons in the hippocampus of rats after an …
staining around parvalbumin‐positive interneurons in the hippocampus of rats after an …
[HTML][HTML] The perineuronal 'safety'net? Perineuronal net abnormalities in neurological disorders
Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …
[HTML][HTML] Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy
Brain tumor patients commonly present with epileptic seizures. We show that tumor-
associated seizures are the consequence of impaired GABAergic inhibition due to an overall …
associated seizures are the consequence of impaired GABAergic inhibition due to an overall …
Casting a wide net: role of perineuronal nets in neural plasticity
BA Sorg, S Berretta, JM Blacktop… - Journal of …, 2016 - Soc Neuroscience
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain
neurons in the CNS during development and control plasticity in the adult CNS. They appear …
neurons in the CNS during development and control plasticity in the adult CNS. They appear …
Perineuronal nets in brain physiology and disease
D Testa, A Prochiantz, AA Di Nardo - Seminars in cell & developmental …, 2019 - Elsevier
Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular
matrix structures with heterogeneous composition yet specific organization. They typically …
matrix structures with heterogeneous composition yet specific organization. They typically …
The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function
JW Fawcett, T Oohashi, T Pizzorusso - Nature Reviews Neuroscience, 2019 - nature.com
Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …
[HTML][HTML] Quantitative changes in perineuronal nets in development and posttraumatic condition
N Lipachev, N Arnst, A Melnikova, H Jäälinoja… - Journal of molecular …, 2019 - Springer
Perineuronal net (PNN) is a highly structured portion of the CNS extracellular matrix (ECM)
regulating synaptic plasticity and a range of pathologic conditions including posttraumatic …
regulating synaptic plasticity and a range of pathologic conditions including posttraumatic …
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