Risk averse reproduction numbers improve resurgence detection

KV Parag, U Obolski - PLOS Computational Biology, 2023 - journals.plos.org
The effective reproduction number R is a prominent statistic for inferring the transmissibility
of infectious diseases and effectiveness of interventions. R purportedly provides an easy-to …

Fundamental limits on inferring epidemic resurgence in real time using effective reproduction numbers

KV Parag, CA Donnelly - PLOS Computational Biology, 2022 - journals.plos.org
We find that epidemic resurgence, defined as an upswing in the effective reproduction
number (R) of the contagion from subcritical to supercritical values, is fundamentally difficult …

Improved inference of time-varying reproduction numbers during infectious disease outbreaks

RN Thompson, JE Stockwin, RD van Gaalen… - Epidemics, 2019 - Elsevier
Accurate estimation of the parameters characterising infectious disease transmission is vital
for optimising control interventions during epidemics. A valuable metric for assessing the …

EpiFusion: Joint inference of the effective reproduction number by integrating phylodynamic and epidemiological modelling with particle filtering

C Judge, T Vaughan, T Russell, S Abbott, L du Plessis… - bioRxiv, 2023 - biorxiv.org
Accurately estimating the effective reproduction number (Rt) of a circulating pathogen is a
fundamental challenge in the study of infectious disease. The fields of epidemiology and …

Exploring how generation intervals link strength and speed of epidemics

SW Park, D Champredon, JS Weitz, J Dushoff - bioRxiv, 2018 - biorxiv.org
Infectious-disease outbreaks are often characterized by the reproductive number and
exponential rate of growth r. The reproductive number is of particular interest, because it …

Beyond R0: heterogeneity in secondary infections and probabilistic epidemic forecasting

L Hébert-Dufresne, BM Althouse… - Journal of the …, 2020 - royalsocietypublishing.org
The basic reproductive number, R 0, is one of the most common and most commonly
misapplied numbers in public health. Often used to compare outbreaks and forecast …

Beyond R0: the importance of contact tracing when predicting epidemics

L Hébert-Dufresne, BM Althouse, SV Scarpino, A Allard - medRxiv, 2020 - medrxiv.org
The basic reproductive number—R 0—is one of the most common and most commonly
misapplied numbers in public health. Nevertheless, estimating R 0 for every transmissible …

Heterogeneity in the onwards transmission risk between local and imported cases affects practical estimates of the time-dependent reproduction number

R Creswell, D Augustin, I Bouros… - … of the Royal …, 2022 - royalsocietypublishing.org
During infectious disease outbreaks, inference of summary statistics characterizing
transmission is essential for planning interventions. An important metric is the time …

Optimising renewal models for real-time epidemic prediction and estimation

KV Parag, CA Donnelly - bioRxiv, 2019 - biorxiv.org
The effective reproduction number, R t, is a key prognostic of the growth rate of an infectious
disease epidemic. Significant changes in R t could forewarn about new transmission paths …

CHASING R0: UNDERSTANDING THE EFFECTS OF POPULATION DYNAMICS ON THE BASIC REPRODUCTION NUMBER

TV Johnson, AR Mikler - Journal of Biological Systems, 2011 - World Scientific
Preparation for pandemic events depends heavily on understanding specific disease
characteristics and predicting the dynamics of a particular outbreak. The basic reproduction …