Infertility is a major global health issue and male factors account for half of all infertility
cases. One of the causes of male infertility is the loss of spermatogonial stem cells, which …

Background Environmental pollution and infertility are two modern global challenges that
agonize personal and public health. The causal relationship between these two deserves …

The pineal hormone melatonin regulates testicular function through the hypothalamic-
adenohypophyseal axis. In addition, direct actions of melatonin in somatic cells of the testis …

Melatonin is a neurohormone secreted by the pineal gland whose concentrations in the
body are regulated by both the dark–light and seasonal cycles. The reproductive function of …

Spermatogenesis, an intricate process occurring in the testis, is responsible for ongoing
production of spermatozoa and thus the cornerstone of lifelong male fertility. In the testis …

Melatonin is a ubiquitous indoleamine hormone synthesized primarily by the pineal gland.
Diverse biological actions of melatonin involve quite complex mechanisms via its membrane …

Melatonin has a wide variety of beneficial actions at the level of the gonads and their
adnexa. Some actions are mediated via its classic membrane melatonin receptors while …

Background Modern societies face infertility as a global challenge. There are certain
environmental conditions and disorders that damage testicular tissue and may cause male …

Melatonin, conventionally accepted as a pineal gland secretion, is a neuromodulator whose
physiological concentrations are regulated by circadian rhythms. Alteration in melatonin …

Antioxidant actions of melatonin and its impact on testicular function and fertility have
already been described. Considering that Sertoli cells contribute to provide structural …