A cell-cell communication signal integrates quorum sensing and stress response

J Lee, J Wu, Y Deng, J Wang, C Wang, J Wang… - Nature chemical …, 2013 - nature.com
Pseudomonas aeruginosa uses a hierarchical quorum sensing (QS) network consisting of
las, pqs and rhl regulatory elements to coordinate the expression of bacterial virulence …

Chemical genetics reveals environment-specific roles for quorum sensing circuits in Pseudomonas aeruginosa

MA Welsh, HE Blackwell - Cell chemical biology, 2016 - cell.com
Nutritional cues differentially influence the activities of the three quorum sensing (QS)
circuits—Las, Rhl, and Pqs—in the pathogen Pseudomonas aeruginosa. A full …

Molecular mechanisms of phosphate stress activation of Pseudomonas aeruginosa quorum sensing systems

X Meng, SD Ahator, LH Zhang - MSphere, 2020 - Am Soc Microbiol
The hierarchical quorum sensing (QS) systems of Pseudomonas aeruginosa, consisting of
las, pqs, and rhl, coordinate the expression of bacterial virulence genes. Previous studies …

Evolution of the Pseudomonas aeruginosa quorum-sensing hierarchy

M Kostylev, DY Kim, NE Smalley… - Proceedings of the …, 2019 - National Acad Sciences
The bacterial pathogen Pseudomonas aeruginosa activates expression of many virulence
genes in a cell density-dependent manner by using an intricate quorum-sensing (QS) …

Small Molecule Disruption of Quorum Sensing Cross-Regulation in Pseudomonas aeruginosa Causes Major and Unexpected Alterations to Virulence Phenotypes

MA Welsh, NR Eibergen, JD Moore… - Journal of the …, 2015 - ACS Publications
The opportunistic pathogen Pseudomonas aeruginosa uses three interwoven quorum-
sensing (QS) circuits Las, Rhl, and Pqs to regulate the global expression of myriad …

PqsE is essential for RhlR-dependent quorum sensing regulation in Pseudomonas aeruginosa

MC Groleau, T de Oliveira Pereira, V Dekimpe… - Msystems, 2020 - Am Soc Microbiol
The bacterium Pseudomonas aeruginosa has emerged as a central threat in health care
settings and can cause a large variety of infections. It expresses an arsenal of virulence …

The Rhl quorum-sensing system is at the top of the regulatory hierarchy under phosphate-limiting conditions in Pseudomonas aeruginosa PAO1

MP Soto-Aceves, M Cocotl-Yañez… - Journal of …, 2021 - Am Soc Microbiol
Pseudomonas aeruginosa is a major nosocomial pathogen that presents high-level
resistance to antibiotics. Its ability to cause infections relies on the production of multiple …

PqsE expands and differentially modulates the RhlR quorum sensing regulon in Pseudomonas aeruginosa

M Letizia, M Mellini, A Fortuna, P Visca… - Microbiology …, 2022 - Am Soc Microbiol
In the opportunistic pathogen Pseudomonas aeruginosa, many virulence traits are finely
regulated by quorum sensing (QS), an intercellular communication system that allows the …

A unique regulator controls the activation threshold of quorum-regulated genes in Pseudomonas aeruginosa

R Siehnel, B Traxler, DD An… - Proceedings of the …, 2010 - National Acad Sciences
Quorum-sensing (QS) systems allow organisms, such as the pathogen Pseudomonas
aeruginosa, to link gene expression with their population density and the diffusion and flow …

RsaL provides quorum sensing homeostasis and functions as a global regulator of gene expression in Pseudomonas aeruginosa

G Rampioni, M Schuster, EP Greenberg… - Molecular …, 2007 - Wiley Online Library
The quorum sensing (QS) signalling system of Pseudomonas aeruginosa controls many
important functions, including virulence. Although the production of the QS signal molecule …