[HTML][HTML] The bright and the dark side of TGF-β signaling in hepatocellular carcinoma: mechanisms, dysregulation, and therapeutic implications

MZ Gungor, M Uysal, S Senturk - Cancers, 2022 - mdpi.com
Simple Summary Transforming growth factor β (TGF-β) signaling is a preeminent regulator
of diverse cellular and physiological processes. Frequent dysregulation of TGF-β signaling …

[HTML][HTML] The TGF-β pathway: a pharmacological target in hepatocellular carcinoma?

E Gonzalez-Sanchez, J Vaquero… - Cancers, 2021 - mdpi.com
Simple Summary Transforming Growth Factor-beta (TGF-β) signaling is crucial to maintain
tissue homeostasis. Alterations in TGF-β signaling impact tissue functions and favor the …

[HTML][HTML] Contextual regulation of TGF-β signaling in liver cancer

S Tu, W Huang, C Huang, Z Luo, X Yan - Cells, 2019 - mdpi.com
Primary liver cancer is one of the leading causes for cancer-related death worldwide.
Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that signals through …

Transforming growth factor-β as a therapeutic target in hepatocellular carcinoma

G Giannelli, E Villa, M Lahn - Cancer research, 2014 - AACR
Hepatocellular carcinoma arises in patients as a consequence of long-standing preexisting
liver illnesses, including viral hepatitis, alcohol abuse, or metabolic disease. In such …

TGF-β signaling in onset and progression of hepatocellular carcinoma

NM Meindl-Beinker, K Matsuzaki, S Dooley - Digestive diseases, 2012 - karger.com
Transforming growth factor (TGF)-β is a central regulator in chronic liver disease,
contributing to all stages of disease progression from initial liver injury through inflammation …

TGF-β and hepatocellular carcinoma: when a friend becomes an enemy

M Arrese, A Hernandez, L Astete… - Current Protein and …, 2018 - ingentaconnect.com
Hepatocellular carcinoma (HCC) is the third most common cause of cancer death worldwide
accounting for more than 700 thousand deaths per year. Most of the HCC develops in a …

[HTML][HTML] The dichotomous role of TGF-β in controlling liver cancer cell survival and proliferation

K Zhang, M Zhang, Z Luo, Z Wen, X Yan - Journal of Genetics and …, 2020 - Elsevier
Hepatocellular carcinoma (HCC) is the major form of primary liver cancer and one of the
most prevalent and life-threatening malignancies globally. One of the hallmarks in HCC is …

Inhibiting TGF-β signaling in hepatocellular carcinoma

G Giannelli, A Mazzocca, E Fransvea, M Lahn… - … et Biophysica Acta (BBA …, 2011 - Elsevier
One of the main complications in patients with liver fibrosis is the development of
hepatocellular carcinoma (HCC). An understanding of the molecular mechanisms leading to …

The rationale for targeting TGF‐β in chronic liver diseases

G Giannelli, W Mikulits, S Dooley… - European Journal of …, 2016 - Wiley Online Library
Background Transforming growth factor (TGF)‐β is a pluripotent cytokine that displays
several tissue‐specific biological activities. In the liver, TGF‐β is considered a fundamental …

The TGF-β signaling pathway as a pharmacological target in a hepatocellular carcinoma

A Mazzocca, S Antonaci… - Current pharmaceutical …, 2012 - ingentaconnect.com
Hepatocellular carcinoma (HCC) is a cancer that usually develops on a liver already
compromised by cirrhosis. Study of the underlying molecular mechanisms is essential so as …