[HTML][HTML] Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles
Abstract The serotonin 2 receptor (5HT2R) agonist psilocybin displays rapid and persistent
therapeutic efficacy across neuropsychiatric disorders characterized by cognitive inflexibility …
therapeutic efficacy across neuropsychiatric disorders characterized by cognitive inflexibility …
Acute psilocybin enhances cognitive flexibility in rats
Psilocybin has been shown to improve symptoms of depression and anxiety when combined
with psychotherapy or other clinician-guided interventions. To understand the neural basis …
with psychotherapy or other clinician-guided interventions. To understand the neural basis …
Psilocybin facilitates fear extinction: Importance of dose, context, and serotonin receptors
SC Woodburn, CM Levitt, AM Koester… - ACS Chemical …, 2024 - ACS Publications
A variety of classic psychedelics and MDMA have been shown to enhance fear extinction in
rodent models. This has translational significance because a standard treatment for post …
rodent models. This has translational significance because a standard treatment for post …
Probing the antidepressant potential of psilocybin: integrating insight from human research and animal models towards an understanding of neural circuit mechanisms
J Meccia, J Lopez, RC Bagot - Psychopharmacology, 2023 - Springer
Interest in the therapeutic potential of serotonergic psychedelic compounds including
psilocybin has surged in recent years. While human clinical research suggests psilocybin …
psilocybin has surged in recent years. While human clinical research suggests psilocybin …
Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder
Psilocybin has shown promise for the treatment of mood disorders, which are often
accompanied by cognitive dysfunction including cognitive rigidity. Recent studies have …
accompanied by cognitive dysfunction including cognitive rigidity. Recent studies have …
Brain dynamics predictive of response to psilocybin for treatment-resistant depression
Psilocybin therapy for depression has started to show promise, yet the underlying causal
mechanisms are not currently known. Here, we leveraged the differential outcome in …
mechanisms are not currently known. Here, we leveraged the differential outcome in …
Psilocybin analog 4-OH-DiPT enhances fear extinction and GABAergic inhibition of principal neurons in the basolateral amygdala
Psychedelics such as psilocybin show great promise for the treatment of depression and
PTSD, but their long duration of action poses practical limitations for patient access. 4-OH …
PTSD, but their long duration of action poses practical limitations for patient access. 4-OH …
Psilocybin restrains activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms
Psilocybin has shown promise for alleviating symptoms of depression and is currently in
clinical trials for the treatment of anorexia nervosa (AN), a condition that is characterised by …
clinical trials for the treatment of anorexia nervosa (AN), a condition that is characterised by …
Psilocybin prevents activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms
Psilocybin has shown promise for alleviating symptoms of depression and is currently in
clinical trials for the treatment of anorexia nervosa (AN), a condition that is characterised by …
clinical trials for the treatment of anorexia nervosa (AN), a condition that is characterised by …
[HTML][HTML] Cellular rules underlying psychedelic control of prefrontal pyramidal neurons
TG Ekins, I Brooks, S Kailasa, C Rybicki-Kler… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Classical psychedelic drugs are thought to increase excitability of pyramidal cells in
prefrontal cortex via activation of serotonin 2 A receptors (5-HT2 A Rs). Here, we instead find …
prefrontal cortex via activation of serotonin 2 A receptors (5-HT2 A Rs). Here, we instead find …