Objective To evaluate progressive white matter (WM) degeneration in amyotrophic lateral
sclerosis (ALS). Methods Sixty-six patients with ALS and 43 healthy controls were enrolled …

Background The results of recent diffusion tensor imaging (DTI) studies on amyotrophic
lateral sclerosis (ALS) are inconclusive and controversial. We performed a voxel-based …

Background A relevant fraction of patients with amyotrophic lateral sclerosis (ALS) exhibit a
fronto-temporal pattern of cognitive and behavioural disturbances with pronounced deficits …

Background: Cross-sectional imaging studies offer valuable pathological insights into the
neurodegenerative changes of amyotrophic lateral sclerosis. However, clinical trials urgently …

BACKGROUND AND PURPOSE: The extensive application of advanced MR imaging
techniques to the study of ALS has undoubtedly improved our knowledge of disease …

Background White matter (WM) impairment is a hallmark of amyotrophic lateral sclerosis
(ALS). This study evaluated the capacity of mean apparent propagator magnetic resonance …

BACKGROUND AND PURPOSE: ALS leads to macrostructural (ie, cortical atrophy and
hyperintensities along the corticospinal tract) and microstructural (ie, gray matter intrinsic …

Whether longitudinal diffusion tensor MRI imaging (DTI) can capture disease progression in
patients with amyotrophic lateral sclerosis (ALS) is unclear. The primary goal of this study …

BACKGROUND AND PURPOSE: Most DTI studies in ALS have been limited to the
assessment of the CST damage. In this study, we used DTI tractography to investigate …

Previous neuroimaging studies have revealed that both gray matter (GM) and white matter
(WM) are altered in several morphological aspects in amyotrophic lateral sclerosis (ALS) …