Precision aging: applying precision medicine to the field of cognitive aging

L Ryan, M Hay, MJ Huentelman, A Duarte… - Frontiers in aging …, 2019 - frontiersin.org
The current “one size fits all” approach to our cognitive aging population is not adequate to
close the gap between cognitive health span and lifespan. In this review article, we present …

Hypertension and age-related cognitive impairment: common risk factors and a role for precision aging

M Hay, C Barnes, M Huentelman, R Brinton… - Current Hypertension …, 2020 - Springer
Abstract Purpose of Review Precision Aging® is a novel concept that we have recently
employed to describe how the model of precision medicine can be used to understand and …

Conceptualizing healthy cognitive aging: The role of time and variability

EA Rodrigues, S Moreno - Frontiers in Human Neuroscience, 2023 - frontiersin.org
The interest in healthy cognitive aging (HCA) has increased substantially over the past
decade. Researchers are interested in exploring how health can be promoted and cognitive …

Decline and compensation in aging brain and cognition: Promises and constraints

N Raz - Neuropsychology review, 2009 - Springer
Age-related cognitive declines are common and inevitable, but life trajectories of brain and
cognitive functions are variable and plastic. To identify the mechanisms of decline, the …

Health-related heterogeneity in brain aging and associations with longitudinal change in cognitive function

J Wrigglesworth, J Ryan, PGD Ward… - Frontiers in Aging …, 2023 - frontiersin.org
Introduction Neuroimaging-based 'brain age'can identify individuals with 'advanced'or
'resilient'brain aging. Brain-predicted age difference (brain-PAD) is predictive of cognitive …

Neurogenetic effects on cognition in aging brains: a window of opportunity for intervention?

I Reinvang, IJ Deary, AM Fjell, VM Steen… - Frontiers in Aging …, 2010 - frontiersin.org
Knowledge of genetic influences on cognitive aging can constrain and guide interventions
aimed at limiting age-related cognitive decline in older adults. Progress in understanding the …

Time for a systems biological approach to cognitive aging?—a critical review

D Ebaid, SG Crewther - Frontiers in Aging Neuroscience, 2020 - frontiersin.org
The underlying premise of current theories of cognitive decline with age tend to be primarily
cognitive or biological explanations, with relatively few theories adequately integrating both …

[HTML][HTML] Selective vulnerabilities and biomarkers in neurocognitive aging

Z Reagh, M Yassa - F1000Research, 2017 - ncbi.nlm.nih.gov
As the world's population continues to age, an understanding of the aging brain becomes
increasingly crucial. This review focuses on several recent ideas and findings in the study of …

BioAge: toward a multi-determined, mechanistic account of cognitive aging

CA DeCarlo, HA Tuokko, D Williams, RA Dixon… - Ageing research …, 2014 - Elsevier
The search for reliable early indicators of age-related cognitive decline represents a critical
avenue for progress in aging research. Chronological age is a commonly used …

A Subtype Perspective on Cognitive Trajectories in Healthy Aging

EA Rodrigues, GJ Christie, T Cosco, F Farzan… - Brain Sciences, 2024 - mdpi.com
Cognitive aging is a complex and dynamic process characterized by changes due to
genetics and environmental factors, including lifestyle choices and environmental exposure …