Using Nucleic Acid Scavengers to Limit Innate Immune Activation on Cancer Cells and Thereby Inhibit Metastasis

EOU Eteshola - 2021 - search.proquest.com
Breast cancers (BC) remain the most lethal malignancies amongst women. Subtype
heterogeneity and aggressive invasion are believed to be major contributors for poor …

Nucleic-Acid Scavengers Mitigate Breast Cancer Induced Inflammation, Invasion, and Metastasis

EOU Eteshola, K Landa, RE Rempel… - Invasion, and …, 2020 - papers.ssrn.com
Breast cancer (BC) is the most common malignancy in women. Particular subtypes with
aggressive behavior are major contributors to poor outcomes. Triple‑negative breast cancer …

[HTML][HTML] Controlling cancer-induced inflammation with a nucleic acid scavenger prevents lung metastasis in murine models of breast cancer

EK Holl, V Frazier, K Landa, D Boczkowski… - Molecular Therapy, 2021 - cell.com
Tumor cells release nucleic acid-containing proinflammatory complexes, termed nucleic
acid-containing damage-associated molecular patterns (NA DAMPs), passively upon death …

[HTML][HTML] Breast cancer-derived DAMPs enhance cell invasion and metastasis, while nucleic acid scavengers mitigate these effects

EOU Eteshola, K Landa, RE Rempel, IA Naqvi… - … Therapy-Nucleic Acids, 2021 - cell.com
Breast cancer (BC) is the most common malignancy in women. Particular subtypes with
aggressive behavior are major contributors to poor outcomes. Triple-negative breast cancer …

Development of Albumin-Hitchhiking siRNA Conjugates for Therapeutic Mcl-1 Silencing in Triple Negative Breast Cancer

EN Hoogenboezem - 2022 - ir.vanderbilt.edu
Triple negative breast cancer (TNBC) is characterized by a lack of estrogen receptor,
progesterone receptor, and HER2. Patients with TNBC therefore cannot benefit from …

[图书][B] Drug combination nanoparticles targeted to ICAM-1 on breast cancer cells enhance cellular drug exposure in vitro and in mouse model

L Zhu - 2021 - search.proquest.com
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression
of 3 cell receptors--the estrogen receptor (ER), progesterone receptor (PR) and epidermal …

Nanoparticle Cargo Delivery to Metastatic Breast Cancer via Tumor Associated Targeting Schemes

G Covarrubias - 2021 - search.proquest.com
The high morbidity associated with triple negative breast cancers (TNBCs) is directly related
to its high risk of recurrence. TNBC recurrence is often invasive-leading to its metastasis …

[HTML][HTML] RNA nanoparticles for targeted therapies of triple-negative breast cancers

L Danai, E Ge, KA Afonin - Molecular Therapy-Nucleic Acids, 2023 - cell.com
Breast cancer represents the most frequently diagnosed malignancy among women with
10%–20% of all cases involving the deadliest of all subtypes, triple-negative breast cancer …

[图书][B] Nanoparticle-mediated delivery of antibodies and/or RNA for gene regulation in triple-negative breast cancer

MN Dang - 2022 - search.proquest.com
Triple-negative breast cancer (TNBC) is an aggressive disease that is unsusceptible to most
current targeted or hormonal therapies because it lacks expression of the three receptors …

[HTML][HTML] Metastatic breast cancer: Review of emerging nanotherapeutics

R Dissanayake, R Towner, M Ahmed - Cancers, 2023 - mdpi.com
Simple Summary Breast cancer that spreads to other parts of the body, known as metastatic
breast cancer, is a serious and life-threatening condition, leading to decreased survival …