A new genetic strategy for targeting microglia in development and disease

GL McKinsey, CO Lizama, AE Keown-Lang, A Niu… - elife, 2020 - elifesciences.org
As the resident macrophages of the brain and spinal cord, microglia are crucial for the
phagocytosis of infectious agents, apoptotic cells and synapses. During brain injury or …

[PDF][PDF] A combination of ontogeny and CNS environment establishes microglial identity

FC Bennett, ML Bennett, F Yaqoob, SB Mulinyawe… - Neuron, 2018 - cell.com
Microglia, the brain's resident macrophages, are dynamic CNS custodians with surprising
origins in the extra-embryonic yolk sac. The consequences of their distinct ontogeny are …

Investigating microglia in health and disease: challenges and opportunities

VE Miron, J Priller - Trends in Immunology, 2020 - cell.com
Microglia are tissue-resident macrophages implicated in central nervous system (CNS)
development, homeostasis, and response to injury. Recent advances in transcriptomics …

A novel microglial subset plays a key role in myelinogenesis in developing brain

A Wlodarczyk, IR Holtman, M Krueger, N Yogev… - The EMBO …, 2017 - embopress.org
Microglia are resident macrophages of the central nervous system that contribute to
homeostasis and neuroinflammation. Although known to play an important role in brain …

Genetic targeting of microglia

P Wieghofer, KP Knobeloch, M Prinz - Glia, 2015 - Wiley Online Library
Genetic targeting of microglia and other myeloid cells in the central nervous system (CNS) is
highly desirable as they are critical effectors and regulators of changes in CNS homeostasis …

The influence of environment and origin on brain resident macrophages and implications for therapy

ML Bennett, FC Bennett - Nature neuroscience, 2020 - nature.com
Microglia are the tissue-resident macrophages of the brain and spinal cord. They are critical
players in the development, normal function, and decline of the CNS. Unlike traditional …

[HTML][HTML] Isolation and phenotyping of adult mouse microglial cells

K Grabert, BW McColl - Macrophages: Methods and Protocols, 2018 - Springer
Microglia are the resident macrophages of the central nervous system parenchyma and fulfill
crucial roles in brain development, homeostasis, and inflammation. The isolation of a pure …

Fate mapping analysis reveals that adult microglia derive from primitive macrophages

F Ginhoux, M Greter, M Leboeuf, S Nandi, P See… - Science, 2010 - science.org
Microglia are the resident macrophages of the central nervous system and are associated
with the pathogenesis of many neurodegenerative and brain inflammatory diseases; …

A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages

S Brioschi, JA Belk, V Peng, M Molgora, PF Rodrigues… - Immunity, 2023 - cell.com
Genetic tools to target microglia specifically and efficiently from the early stages of
embryonic development are lacking. We generated a constitutive Cre line controlled by the …

Brain parenchymal and extraparenchymal macrophages in development, homeostasis, and disease

S Brioschi, Y Zhou, M Colonna - The Journal of Immunology, 2020 - journals.aai.org
Microglia are parenchymal macrophages of the CNS; as professional phagocytes they are
important for maintenance of the brain's physiology. These cells are generated through …