The two main proteolytic machineries of eukaryotic cells, lysosomes and proteasomes,
receive substrates by different routes. Polyubiquitination targets proteins for proteasomal …

Next to the proteasome, autophagy is the main catabolic pathway for the degradation of
cytoplasmic constituents. The immune system uses it both as an effector mechanism to clear …

Autophagy plays an important role in maintaining intracellular homeostasis by promoting the
transit of cytoplasmic material, such as proteins, organelles and pathogens, for degradation …

Cells digest portions of their interiors in a process known as autophagy to recycle nutrients,
remodel and dispose of unwanted cytoplasmic constituents. This ancient pathway …

Autophagy delivers cytoplasmic constituents for lysosomal degradation. Recent studies
have demonstrated that this pathway mediates resistance to pathogens and is targeted for …

Autophagy is an evolutionarily conserved homeostatic process by which cells deliver
cytoplasmic material for degradation into lysosomes. Autophagy may have evolved as a …

Autophagy constitutes a mechanism for the sequestration and lysosomal degradation of
various cytoplasmic structures, including damaged organelles and invading …

Autophagy is an intracellular homeostatic mechanism important for the degradation of waste
components from the cytoplasm in acidic lysosomal compartments. Originally, surplus parts …

Autophagy is a cytoplasmic homeostasis pathway, enabling cells to digest their own cytosol,
remove toxic protein aggregates, and eliminate defective or surplus organelles. A plenitude …

Autophagy is a homeostatic process whereby cytosol or intracellular organelles are
sequestered by a double membrane structure termed autophagosome for subsequent …