Hydrophilic matrix systems are one of the most interesting drug delivery systems, and they
are currently some of the most widely used to control the release rate of drugs. There are too …

Purpose. The aims of this study were (i) to elucidate the transport mechanisms involved in
drug release from hydrophilic matrices; and (ii) to develop an improved mathematical model …

Hydrophilic matrices are an interesting option when developing an oral sustained-release
formulation. Entering the field of pharmaceutical technology almost 40 years ago, they have …

Design and realization of drug delivery systems based on polymer matrices could be greatly
improved by modeling the phenomena which take place after the systems administration …

Matrices are manufactured by direct compression of a powder mixture of a polymer, eg,
methylhydroxypropyl cellulose (MHPC) or polyvinylalcohol (PVAI), and a drug. The following …

Drug release mechanisms of swellable systems for controlled drug administration were
investigated. The variations of the matrix relaxation and drug diffusion rates were quantified …

The release of 23 drugs of various solubilities and molecular weights through matrices of
hydroxypropylmethylcellulose (HPMC; matrix I) and a mixture (1: 1) of HPMC and sodium …

Hydroxypropylmethylcellulose (HPMC) represents the most frequently used polymer in the
formulation of hydrogel matrices for controlled drug delivery. Drug release from these …

Oral controlled drug delivery has gathered tremendous attention over the years due to its
many advantages over conventional dosage forms. Polymer-based matrices have become …

Controlled drug delivery systems (CDDS) have emerged as a very powerful tool in the last
few decades to overcome the problems associated with conventional dosage forms such as …