Cancer heterogeneity, a hallmark enabling clonal survival and therapy resistance, is shaped
by active immune responses. Antigen-specific T cells can control cancer, as revealed …

The development of cancer immunotherapies has been guided by advances in our
understanding of the dynamics between tumor cells and immune populations. An emerging …

Cancer immunotherapy is demonstrating impressive clinical benefit in different malignancies
and clinical oncologists are increasingly turning their attention to immune-oncology. It is now …

Immunotherapy is revolutionizing the clinical management of multiple tumors. However, only
a fraction of patients with cancer responds to immunotherapy, and currently available …

Conventional anticancer therapies, such as chemotherapy, radiotherapy, and targeted
therapy, are designed to kill cancer cells. However, the efficacy of anticancer therapies is not …

Understanding the spontaneous immune response of cancer patients is critical for the
design of efficient anticancer immunotherapies. The power of integrative tumor immunology …

Owing to their tremendous diversity and plasticity, immune cells exert multifaceted functions
in tumor-bearing hosts, ranging from anti-tumor to pro-tumor activities. Tumor immune …

Tumor cells often evoke specific immune responses that, however, fail to eliminate all the
tumor cells. The development of cancer immunotherapies is, therefore, mostly focused on …

Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor
immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and …

Conventional treatment for cancer routinely includes surgical resection and some
combination of chemotherapy and radiation. These approaches are frequently accompanied …